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In the fields of medicine, biotechnology, and pharmacology, drug discovery is the process by which new candidate medications are discovered. [1] Historically, drugs were discovered by identifying the active ingredient from traditional remedies or by serendipitous discovery, as with penicillin.
Drug Research is abstracted and indexed in: . Biological Abstracts; Chemical Abstracts; Excerpta Medica; Index Medicus; Nuclear Science Abstracts; According to the Journal Citation Reports, it has a 2014 impact factor of 0.701, ranking it 121st out of 157 journals in the category "Chemistry, multidisciplinary" [1] and 229th out of 254 journals in the category "Pharmacology & Pharmacy".
Drug development is the process of bringing a new pharmaceutical drug to the market once a lead compound has been identified through the process of drug discovery.It includes preclinical research on microorganisms and animals, filing for regulatory status, such as via the United States Food and Drug Administration for an investigational new drug to initiate clinical trials on humans, and may ...
For drug development, the clinical phases start with testing for drug safety in a few human subjects, then expand to many study participants (potentially tens of thousands) to determine if the treatment is effective. [1] Clinical research is conducted on drug candidates, vaccine candidates, new medical devices, and new diagnostic assays.
21st century begins with the first complete sequences of individual human genomes by Human Genome Project, on 12 February 2001, this allowed a switch in drug development and research from the traditional way of drug discovery that was isolating molecules from plants or animals or create new molecules and see if they could be useful in treatment ...
Version 3.0 also included drug transporter data, drug pathway data, drug pricing, patent and manufacturing data as well as data on >5000 experimental drugs. Version 4.0 was released in 2014. [ 4 ] This version included 1558 FDA-approved small molecule drugs, 155 biotech drugs and 4200 unique drug targets.
Center for Pharmaceutical Research and Innovation; Chemical library; Chemical similarity; Cheminformatics; Chemogenomics; Classical pharmacology; Clinical trial; Combinatorial chemistry; Compound management; Cost of drug development; COVID-19 drug development; Critical Path Institute; Discovery and development of cyclooxygenase 2 inhibitors
The United States Food and Drug Administration's Investigational New Drug (IND) program is the means by which a pharmaceutical company obtains permission to start human clinical trials and to ship an experimental drug across state lines (usually to clinical investigators) before a marketing application for the drug has been approved.