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Cytochrome P450, family 1, subfamily A, polypeptide 1 is a protein [5] that in humans is encoded by the CYP1A1 gene. [6] The protein is a member of the cytochrome P450 superfamily of enzymes. [ 7 ]
The enzyme encoded by this gene localizes to the endoplasmic reticulum and metabolizes procarcinogens such as polycyclic aromatic hydrocarbons and 17beta-estradiol. Despite over 20 years of research on CYP1A1 and CYP1A2, CYP1B1 was not identified and sequenced until 1994. Nucleic and amino acid analysis showed approximately 40% identity with ...
When the high-affinity AHR ligand FICZ binds to the receptor, which is a ligand dependent transcription factor, activation of many target genes takes place. The most well-studied of these target genes is the cytochrome P450 (CYP) 1A1. The CYPs are a superfamily of enzymes involved in the metabolism of a large number of both endogenous and ...
Cytochrome P450 1A2 (abbreviated CYP1A2), a member of the cytochrome P450 mixed-function oxidase system, is involved in the metabolism of xenobiotics in the human body. [5] In humans, the CYP1A2 enzyme is encoded by the CYP1A2 gene .
Humans have 57 genes and more than 59 pseudogenes divided among 18 families of cytochrome P450 genes and 43 subfamilies. [23] This is a summary of the genes and of the proteins they encode. See the homepage of the cytochrome P450 Nomenclature Committee for detailed information. [5]
The presence of neurofibrillary tangles in the brain is one of the key hallmarks of Alzheimer’s disease. These irregular clumps of protein are closely associated with disease progression.
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Through the action of CYP1A1, CYP1A2, CYP2C8, and the CYP3A isoforms, 16α-hydroxyestradiol (16α-OHE 2), also known as estriol, is produced in abundance during pregnancy. 16α-OHE 2 can be dehydrogenated to 16α-hydroxyestrone (16α-OHE 1), a metabolite that has been shown to bind covalently to the estrogen receptor via Schiff base formation. [11]