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1544 13077 Ensembl ENSG00000140505 ENSMUSG00000032310 UniProt P05177 P00186 RefSeq (mRNA) NM_000761 NM_009993 RefSeq (protein) NP_000752 NP_034123 Location (UCSC) Chr 15: 74.75 – 74.76 Mb Chr 9: 57.58 – 57.59 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Cytochrome P450 1A2 (abbreviated CYP1A2), a member of the cytochrome P450 mixed-function oxidase system, is involved in the ...
CYP1A1 also metabolizes polyunsaturated fatty acids into signaling molecules that have physiological as well as pathological activities. CYP1A1 has monoxygenase activity in that it metabolizes arachidonic acid to 19-hydroxyeicosatetraenoic acid (19-HETE) (see 20-Hydroxyeicosatetraenoic acid) but also has epoxygenase activity in that it metabolizes docosahexaenoic acid to epoxides, primarily ...
The fluctuation in the amount of CYP450 enzymes (CYP1A2, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP3A4, and CYP3A5) in phase 1 (detoxification) can have varying effects on individuals, as genetic expression varies from person to person. This variation is due to the enzyme's genetic polymorphism, which leads to variability in its function and expression.
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CYP1A2, CYP3A4, CYP3A5 and CYP2C19 are considered to be the main enzymes involved in clopidogrel metabolism. [19] First clopidogrel is metabolised into 2-oxo-clopidogrel, which in turn is hydrolyzed to the active metabolism which is a thiol .
The location of the inhibition occurs in the lining of the intestines, not within the liver. [30] The effects last because grapefruit-mediated inhibition of drug metabolizing enzymes, like CYP3A4 , is irreversible ; [ 30 ] that is, once the grapefruit has "broken" the enzyme, the intestinal cells must produce more of the enzyme to restore their ...
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13078 Ensembl ENSG00000138061 ENSMUSG00000024087 UniProt Q16678 Q64429 RefSeq (mRNA) NM_000104 NM_009994 NM_001364889 RefSeq (protein) NP_000095 NP_034124 NP_001351818 Location (UCSC) Chr 2: 38.07 – 38.11 Mb Chr 17: 80.01 – 80.02 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Cytochrome P450 1B1 is an enzyme that in humans is encoded by the CYP1B1 gene. Function CYP1B1 belongs ...