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β-Glucocerebrosidase (also called acid β-glucosidase, D-glucosyl-N-acylsphingosine glucohydrolase, or GCase) is an enzyme with glucosylceramidase activity (EC 3.2.1.45) that cleaves by hydrolysis the β-glycosidic linkage of the chemical glucocerebroside, an intermediate in glycolipid metabolism that is abundant in cell membranes (particularly skin cells). [5]
It is a recombinant DNA-produced analogue of the human enzyme β-glucocerebrosidase. Cerezyme is a freeze-dried medicine containing imiglucerase, manufactured by Genzyme Corporation. It is given intravenously after reconstitution as a treatment for Type 1 and Type 3 [4] Gaucher's disease. It is available in formulations containing 200 or 400 ...
Gaucher's disease or Gaucher disease (/ ɡ oʊ ˈ ʃ eɪ /) (GD) is a genetic disorder in which glucocerebroside (a sphingolipid, also known as glucosylceramide) accumulates in cells and certain organs.
Loose Women panellist Gloria Hunniford has opened up about the changes she has made to her diet after receiving a warning from her doctor.. The 84-year-old presenter admitted that she has tested ...
Johanna Budwig (1908 – 2003) was a German biochemist, alternative cancer treatment advocate and writer. [1] Budwig was a pharmacist and held doctorate degrees in physics and chemistry. [2] Based on her research on fatty acids she developed a lacto-vegetarian diet that she believed was useful in the treatment of cancer. There is no clinical ...
Velaglucerase alfa, sold under the brand name Vpriv, is a medication used for the treatment of Gaucher disease Type 1. [1] It is a hydrolytic lysosomal glucocerebroside-specific enzyme, which is a recombinant form of glucocerebrosidase. It has an identical amino acid sequence to the naturally occurring enzyme. [2] It is manufactured by Shire plc.
1. Minoxidil. Let’s start this list off with your best option: minoxidil. The generic version of Rogaine®, minoxidil is an FDA-approved treatment available as a liquid, foam and oral medication.
The Dietary Guidelines for Americans have been criticized for recommending a diet that contains less than 2.3 grams of sodium (5.8 grams of salt/day). Notably, 95% of the world's populations have a mean intake of salt that is between 6g and 12g daily and evidence on the health effects of salt does not support such a severe restriction on salt ...
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