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In molecular biology, autophagy related 3 (Atg3) is the E2 enzyme for the LC3 lipidation process. [1] It is essential for autophagy . The super protein complex, the Atg16L complex, consists of multiple Atg12-Atg5 conjugates.
Atg1 is a kinase upregulated upon induction of autophagy. Atg13 regulates Atg1 and together they form a complex called Atg13:Atg1, which receives signals from the master of nutrient sensing – Tor. Atg1 is also important in late stages of autophagosome formation. [8]
The inlet manifold of a reverse-flow cylinder head may be connected to the exhaust by a heat riser to transfer further heat, improving low rpm response and emissions as a result. Costs can be reduced in production engines by casting the inlet and exhaust manifolds as one unit. This also transfers further heat to the inlet eliminating the need ...
Cuervo, AM (13 July 2011). "Chaperone-mediated autophagy: Dice's 'wild' idea about lysosomal selectivity". Nature Reviews Molecular Cell Biology. 12 (8): 535– 41. doi:10.1038/nrm3150. PMID 21750569. S2CID 23128629. Kaushik, S; Cuervo, AM (2009). "Chapter 19 Methods to Monitor Chaperone-Mediated Autophagy". Autophagy in Mammalian Systems, Part ...
Autophagy protein 5 (ATG5) is a protein that, in humans, is encoded by the ATG5 gene located on chromosome 6. It is an E3 ubi autophagic cell death. ATG5 is a key protein involved in the extension of the phagophoric membrane in autophagic vesicles. It is activated by ATG7 and forms a complex with ATG12 and ATG16L1.
Neuroleptic malignant syndrome (NMS) is a rare [5] [6] but life-threatening reaction that can occur in response to antipsychotics (neuroleptic) or other drugs that block the effects of dopamine.
Autophagy (or autophagocytosis; from the Greek αὐτόφαγος, autóphagos, meaning "self-devouring" [1] and κύτος, kýtos, meaning "hollow") [2] is the natural, conserved degradation of the cell that removes unnecessary or dysfunctional components through a lysosome-dependent regulated mechanism. [3]
This autophagic pathway engulfs multivesicular bodies formed after endocytosis therefore it plays role in membrane proteins turnover. [3] Microautophagy is also connected with organellar size maintenance, composition of biological membranes , cell survival under nitrogen restriction, and the transition pathway from starvation-induced growth ...