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4-Fluoroephedrine, also known as 4-fluoro-β-hydroxy-N-methylamphetamine, is a substituted phenethylamine, amphetamine, and β-hydroxyamphetamine derivative. [6] [1] It is the 4-fluoro analogue of ephedrine. [6] [1] The synthesis of 4-fluoroephedrine has been described. [7] It can serve as a precursor in the synthesis of 4-fluoromethamphetamine ...
In 1997, the FDA proposed a regulation on ephedra (the herb from which ephedrine is obtained), which limited an ephedra dose to 8 mg (of active ephedrine) with no more than 24 mg per day. [78] This proposed rule was withdrawn, in part, in 2000 because of "concerns regarding the agency's basis for proposing a certain dietary ingredient level and ...
4-Fluoromethylphenidate was studied further along with other analogues of (±)-threo-methylphenidate (TMP) to assess their potential as anti-cocaine medications. 4F-MPH was reported as having an ED 50 mg/kg of 0.26 (0.18–0.36), regarding its efficacy as a substitute for cocaine, and a relative potency of 3.33 compared to methylphenidate for ...
[3] [4] [1] It is reported to be used in various over-the-counter cough and cold preparations throughout the world, including Japan. [1] The drug is an ephedrine-like sympathomimetic and activates α-and β-adrenergic receptors. [5] Chemically, it is a substituted amphetamine and is closely related to ephedrine. [3] [4]
[4] [5] [6] It is taken by mouth. [1] Oxilofrine acts as a norepinephrine releasing agent and hence is an indirectly acting sympathomimetic. [7] [6] [8] It is a substituted amphetamine and is closely related to ephedrine (with oxilofrine also being known as 4-hydroxyephedrine). [4] [8] Oxilofrine was first developed in the 1930s. [9]
The minimum dose (5 mg/kg) was confirmed in a clinical trial performed by HTI Bio-services, Inc. [5] It evaluated the effective dose for the treatment of an infected dermal wound. The study included forty-eight mixed breed dogs (both male and female) with weights ranging from 14.5-24.5 kilograms. These dogs were randomly placed into treatment ...
4'-Fluorocannabidiol (also known as PECS-101 and 4'-F-CBD, and formerly as HUF-101 and HU-474 [1]) is a fluorinated cannabidiol derivative that has more potent anxiolytic, antidepressant, antipsychotic and anti-compulsive activity in mice compared to its parent compound.
4-Fluoro-deprenyl is metabolized to 4-Fluoromethamphetamine and 4-Fluoroamphetamine, both of which are active. The levels of substituted amphetamine metabolites in the brain is three times higher following 4-fluoroselegiline administration compared to an equivalent dose of selegiline. [2]
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