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The 5-HT 2A receptor is a subtype of the 5-HT 2 receptor that belongs to the serotonin receptor family and is a G protein-coupled receptor (GPCR). [4] The 5-HT 2A receptor is a cell surface receptor, [5] but has several intracellular locations. [6] Like all 5-HT 2 receptors, the 5-HT 2A receptor is G q /G 11-protein coupled.
DOB-2-DRAGONFLY-5-BUTTERFLY is a drug with an unusual furo[2,3-g]chromene core structure which acts as a 5-HT 2A receptor agonist.It was first synthesised by David E. Nichols and colleagues in 2008, and while it is weaker than similar compounds such as Bromo-DragonFLY it is still the most potent among a number of related derivatives.
DOB is a serotonin 5-HT 2A, 5-HT 2B, and 5-HT 2C receptor agonist. [5] [6] Its psychedelic effects are mediated by its agonistic properties at the 5-HT 2A receptor. Due to its selectivity, DOB is often used in scientific research when studying the 5-HT 2 receptor subfamily.
The 5-HT 1B receptor as an example of a metabotropic serotonin receptor. Its crystallographic structure in ribbon representation. 5-HT receptors, 5-hydroxytryptamine receptors, or serotonin receptors, are a group of G protein-coupled receptor and ligand-gated ion channels found in the central and peripheral nervous systems.
Bromo-DragonFLY (or 3C-Bromo-Dragonfly, DOB-Dragonfly [2]) is a substance related to the phenethylamine family. It acts as a potent full agonist for the 5-HT 2A receptor . [ 3 ]
The 5-HT 2 receptors are a subfamily of 5-HT receptors that bind the endogenous neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). [1] The 5-HT 2 subfamily consists of three G protein-coupled receptors (GPCRs) which are coupled to G q /G 11 and mediate excitatory neurotransmission, [2] including 5-HT 2A, 5-HT 2B, and 5-HT 2C. For more ...
This is a list of miscellaneous agonists of the serotonin receptor subtype 5-HT 2A (and other 5-HT 2 subtypes to a varying extent) that fall outside the common structural classes.
Dimethoxybromoamphetamine (DOB; brolamfetamine) – serotonin 5-HT 2A, 5-HT 2B, and 5-HT 2C receptor agonist and psychedelic hallucinogen – unknown – unknown [283] [284] Dimethoxyethylamphetamine (DOET) – serotonin 5-HT 2A , 5-HT 2B , and 5-HT 2C receptor agonist and psychedelic hallucinogen – unknown – Dow Chemical Company [ 285 ]