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[44] [45] Unlike opioids and other sedatives such as propofol, dexmedetomidine is able to achieve its effects without causing respiratory depression. Dexmedetomidine induces sedation by decreasing activity of noradrenergic neurons in the locus ceruleus in the brain stem , thereby increasing the downstream activity of inhibitory γ-aminobutyric ...
Person is nearing end-of-life: Vitals such as heart rate, blood pressure, and oxygen saturation, are monitored to maintain physiological stability through sedation. Depending on the risk of a person to have respiratory depression or become unstable, the treatment dose may need to be adjusted or a benzodiazepine antagonist may be administered.
Aside from the respiratory depression, risks also include unintended levels of sedation, postoperative somnolence, aspiration, [4] and adverse reactions to sedation medications. [5] Complications could also include perforation, bleeding, and the stimulation of vasovagal reflexes . [ 6 ]
Midazolam collects in the body's fatty tissues, so a possible complication includes prolonged sedation. As a result, the elderly, the obese, and those with kidney or liver disease are more vulnerable to prolonged sedation with midazolam. Respiratory depression is also associated with midazolam when given in high doses.
Complications from inhalation sedation are rare, and are those events that require intervention to correct adverse physiological responses. They include over-sedation, respiratory depression/apnoea, unconscious patient, airway obstruction, vomiting, idiosyncratic responses, delayed recovery, and failure of conscious sedation.
This level, called moderate sedation/analgesia or conscious sedation, causes a drug induced depression of consciousness during which the patient responds purposefully to verbal commands, either alone or accompanied with light physical stimulation. Breathing tubes are not required for this type of anesthesia. This is twilight anesthesia. [2]
Anxiety Medications: An Overview. Anxiety disorders are very common, according to the National Institute of Mental Health. An estimated 31.1 percent of all American adults will experience some ...
It is also used as a treatment for depression and in pain management. [19] Ketamine is an NMDA receptor antagonist which accounts for most of its psychoactive effects. [20] At anesthetic doses, ketamine induces a state of dissociative anesthesia, a trance-like state providing pain relief, sedation, and amnesia. [21]