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The LDLR gene resides on chromosome 19 at the band 19p13.2 and is split into 18 exons. [8] Exon 1 contains a signal sequence that localises the receptor to the endoplasmic reticulum for transport to the cell surface.
4043 16976 Ensembl ENSG00000163956 ENSMUSG00000029103 UniProt P30533 P55302 RefSeq (mRNA) NM_002337 NM_013587 RefSeq (protein) NP_002328 NP_038615 Location (UCSC) Chr 4: 3.5 – 3.53 Mb Chr 5: 35.25 – 35.26 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Protein family Alpha-2-MRAP_N haddock model of the complex between double module of lrp, cr56, and first domain of receptor ...
Low density lipoprotein receptor-related protein 1 (LRP1), also known as alpha-2-macroglobulin receptor (A2MR), apolipoprotein E receptor (APOER) or cluster of differentiation 91 (CD91), is a protein forming a receptor found in the plasma membrane of cells involved in receptor-mediated endocytosis. In humans, the LRP1 protein is encoded by the ...
Immunoprecipitation of intact protein complexes (i.e. antigen along with any proteins or ligands that are bound to it) is known as co-immunoprecipitation (Co-IP). Co-IP works by selecting an antibody that targets a known protein that is believed to be a member of a larger complex of proteins.
A reference range is usually defined as the set of values 95 percent of the normal population falls within (that is, 95% prediction interval). [2] It is determined by collecting data from vast numbers of laboratory tests.
Homozygotes have LDLR activity of less than 2%, while heterozygotes have defective LDL processing with receptor activity being 2–25%, depending on the nature of the mutation. Over 1000 different mutations are known. [4] There are five major classes of FH due to LDLR mutations: [12] Class I: LDLR is not synthesized at all.
About a decade ago, another hydrophilicity scale was published, this scale used normal phase liquid chromatography and showed the retention of 121 peptides on an amide-80 column. [28] The absolute values and relative rankings of hydrophobicity determined by chromatographic methods can be affected by a number of parameters.
26119 100017 Ensembl ENSG00000157978 ENSMUSG00000037295 UniProt Q5SW96 Q8C142 RefSeq (mRNA) NM_015627 NM_145554 RefSeq (protein) NP_056442 NP_663529 Location (UCSC) Chr 1: 25.54 – 25.57 Mb Chr 4: 134.47 – 134.5 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Low-density lipoprotein receptor adapter protein 1 is a protein that in humans is encoded by the LDLRAP1 gene. The protein ...
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