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Charles Alderson Janeway, Jr. (February 5, 1943 – April 12, 2003) was an American immunologist who helped create the modern field of innate immunity. [1] A member of the National Academy of Sciences , he held a faculty position at Yale University 's Medical School and was an Howard Hughes Medical Institute Investigator.
Charles Janeway (1943-2003), wrote the standard textbook Immunobiology; Dermot Kelleher; Tadamitsu Kishimoto (1939-) Jan Klein (1936-), Mhc; Mary Loveless (1899-1991), insect venom allergy; Tak Wah Mak (1946-), discovery of the T-cell receptor; Alberto Mantovani; Polly Matzinger (1947-), immunological tolerance, Danger Model, Hyppo Model; Ira ...
The following outline is provided as an overview of and topical guide to immunology: . Immunology – study of all aspects of the immune system in all organisms. [1] It deals with the physiological functioning of the immune system in states of both health and disease; malfunctions of the immune system in immunological disorders (autoimmune diseases, hypersensitivities, immune deficiency ...
[1] Other more recent definitions have remained more or less the same. The 8th edition of Janeway's Immunobiology defines tolerance as "immunologically unresponsive...to another's tissues.". [2] Immune tolerance encompasses the range of physiological mechanisms by which the body reduces or eliminates an immune response to particular agents.
Immunophysics is a novel interdisciplinary research field using immunological, biological, physical and chemical approaches to elucidate and modify immune-mediated mechanisms and to expand our knowledge on the pathomechanisms of chronic immune-mediated diseases such as arthritis, inflammatory bowel disease, asthma and chronic infections.
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1) A hematopoietic stem cell undergoes differentiation and genetic rearrangement to produce 2) immature lymphocytes with many different antigen receptors. Those that bind to 3) antigens from the body's own tissues are destroyed, while the rest mature into 4) inactive lymphocytes. Most of these never encounter a matching
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