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Antihistamines during pregnancy have not been linked to birth defects; however, further research is necessary for some antihistamine medications to determine safety during pregnancy. [56] It is suggested that women speak to their healthcare professionals before taking any over-the-counter or prescription medication while pregnant to ensure that ...
Pyridoxine/doxylamine, sold under the brand name Diclectin among others, is a combination of pyridoxine hydrochloride (vitamin B 6) and doxylamine succinate.It is generally used for nausea and vomiting of pregnancy (morning sickness); even though its efficacy has not been proven and subsequent research has led to the removal of recommendations in medical journals.
[2] [6] Cyclizine appears to be safe during pregnancy but has not been well studied. [7] It is in the anticholinergic and antihistamine family of medications. [3] [6] Cyclizine was discovered in 1947. [8] It is on the World Health Organization's List of Essential Medicines. [9] In the United States it is available over the counter. [6]
Use in pregnancy appears safe but has not been well studied and use when breastfeeding is of unclear safety. [5] It is classified as a second-generation antihistamine and works by blocking histamine H 1-receptors. [6] [3] Levocetirizine was approved for medical use in the United States in 2007, [3] and is available as a generic medication. [4]
Use in pregnancy appears safe, but has not been well studied; use in breastfeeding is of unclear safety. [4] It is believed to work in part by anticholinergic and antihistamine mechanisms. [3] Meclizine was patented in 1951 and came into medical use in 1953. [5] It is available as a generic medication and often over the counter.
Diphenhydramine is contraindicated in premature infants and neonates, as well as people who are breastfeeding. It is a pregnancy Category B drug. Diphenhydramine has additive effects with alcohol and other CNS depressants. Monoamine oxidase inhibitors prolong and intensify the anticholinergic effect of antihistamines. [47]
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