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26395 Ensembl ENSG00000169032 ENSMUSG00000004936 UniProt Q02750 P31938 RefSeq (mRNA) NM_002755 NM_008927 RefSeq (protein) NP_002746 NP_032953 Location (UCSC) Chr 15: 66.39 – 66.49 Mb Chr 9: 64.09 – 64.16 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Dual specificity mitogen-activated protein kinase kinase 1 is an enzyme that in humans is encoded by the MAP2K1 gene. Function The ...
There are seven genes: MAP2K1 (a.k.a. MEK1) MAP2K2 (a.k.a. MEK2) MAP2K3 (a.k.a. MKK3) MAP2K4 (a.k.a. MKK4) MAP2K5 (a.k.a. MKK5) MAP2K6 (a.k.a. MKK6) MAP2K7 (a.k.a. MKK7) The activators of p38 (MKK3 and MKK6), JNK (MKK4 and MKK7), and ERK (MEK1 and MEK2) define independent MAP kinase signal transduction pathways. [1] The acronym MEK derives from ...
The protein encoded by this gene was identified as an interacting protein that binds specifically to MAP kinase kinase MAP2K1/MEK1 and to MAP kinase MAPK2/ERK1.This protein enhances the activation of MAPK2, and thus is thought to function as an adaptor to enhance the efficiency of the MAP kinase cascade.
Bottom, signal enters the cell nucleus and causes transcription of DNA, which is then expressed as protein. The MAPK/ERK pathway (also known as the Ras-Raf-MEK-ERK pathway) is a chain of proteins in the cell that communicates a signal from a receptor on the surface of the cell to the DNA in the nucleus of the cell.
U0126 [1] [2] is the 'code' name for a compound associated with cancer treatment [3] and also in preventing ischemia and cellular oxidative stress. It also has likely utility in strokes and heart attacks. [4] This compound is available for research purposes from a number of companies. [5] [6]
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation , differentiation , transcription regulation and development.
A MEK inhibitor is a chemical or drug that inhibits the mitogen-activated protein kinase kinase enzymes MEK1 and/or MEK2. They can be used to affect the MAPK/ERK pathway which is often overactive in some cancers. (See MAPK/ERK pathway#Clinical significance.)
5605 26396 Ensembl ENSG00000126934 ENSMUSG00000035027 UniProt P36507 Q63932 RefSeq (mRNA) NM_030662 NM_023138 NM_001347144 NM_001358539 RefSeq (protein) NP_109587 NP_001334073 NP_075627 NP_001345468 Location (UCSC) Chr 19: 4.09 – 4.12 Mb Chr 10: 80.94 – 80.97 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Dual specificity mitogen-activated protein kinase kinase 2 is an enzyme ...