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Magnesium bromide is used as a Lewis acid catalyst in some organic synthesis, e.g., in aldol reaction. [5] Magnesium bromide also has been used as a tranquilizer [2] and as an anticonvulsant for treatment of nervous disorders. [6] Magnesium bromide modifies the catalytic properties of palladium on charcoal. [7]
In the Boord olefin synthesis, the addition of magnesium to certain β-haloethers results in an elimination reaction to the alkene. This reaction can limit the utility of Grignard reactions. This reaction can limit the utility of Grignard reactions.
Organocopper complexes in particular react sluggishly in the absence of a Lewis acid. Although magnesium bromide generated in situ from the reaction of Grignard reagents and copper(I) halides can serve this role (see above), external Lewis acids are also useful. In the presence of boron trifluoride etherate, organocopper complexes are able to ...
A solution of a carbonyl compound is added to a Grignard reagent. (See gallery) An example of a Grignard reaction (R 2 or R 3 could be hydrogen). The Grignard reaction (French:) is an organometallic chemical reaction in which, according to the classical definition, carbon alkyl, allyl, vinyl, or aryl magnesium halides (Grignard reagent) are added to the carbonyl groups of either an aldehyde or ...
Magnesium–halogen exchange. Grignard reagents can be prepared by treating a preformed Grignard reagent with an organic halide. This method offers the advantage that the Mg transfer tolerates many functional groups. A typical reaction involves isopropylmagnesium chloride and aryl bromide or iodides: [10] i-PrMgCl + ArCl → i-PrCl + ArMgCl
n-Propylmagnesium bromide, often referred to as simply propylmagnesium bromide, is an organomagnesium compound with the chemical formula C 3 H 6 MgBr. As the Grignard reagent derived from 1-bromopropane , it is used for the n -propylation of electrophiles in organic synthesis.
Completing the cyclooctane ring required 3 more carbon atoms that were supplied by a C2 fragment in an aldol addition and a Grignard C1 fragment (scheme 2).A Mukaiyama aldol addition (magnesium bromide / toluene) took place between aldehyde 7 and ketene silyl acetal 8 with 71% stereoselectivity to alcohol 9 which was protected as the TBS ether 10 (TBSOTf, 2,6-lutidine).
Phenylmagnesium bromide, with the simplified formula C 6 H 5 MgBr, is a magnesium-containing organometallic compound. It is commercially available as a solution in diethyl ether or tetrahydrofuran (THF). Phenylmagnesium bromide is a Grignard reagent. It is often used as a synthetic equivalent for the phenyl "Ph −" synthon.