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Brain-derived neurotrophic factor (BDNF), or abrineurin, [5] is a protein [6] that, in humans, is encoded by the BDNF gene. [7] [8] BDNF is a member of the neurotrophin family of growth factors, which are related to the canonical nerve growth factor (NGF), a family which also includes NT-3 and NT-4/NT-5.
Figure 1: NR1/NR2 NMDA receptor. The NMDA receptor is a glutamate and ion channel protein receptor that is activated when glycine and glutamate bind to it. [5] The receptor is a highly complex and dynamic heteromeric protein that interacts with a multitude of intracellular proteins via three distinct subunits, namely GluN1, GluN2, and GluN3 ...
Further, when BDNF was injected during uncontrollable pain stimulation, it blocked allodynia and enabled rats to learn to not extend their hind legs. [21] Overall, her results and work point to the importance of BDNF in beneficial plasticity in pain models and the potential importance of BDNF in plasticity and recovery after spinal cord injury ...
According to the United States National Library of Medicine's medical subject headings, the term neurotrophin may be used as a synonym for neurotrophic factor, [5] but the term neurotrophin is more generally reserved for four structurally related factors: nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4). [6]
Tropomyosin receptor kinase B (TrkB), [5] [6] [7] also known as tyrosine receptor kinase B, or BDNF/NT-3 growth factors receptor or neurotrophic tyrosine kinase, receptor, type 2 is a protein that in humans is encoded by the NTRK2 gene. [8] TrkB is a receptor for brain-derived neurotrophic factor (BDNF).
6096 225998 Ensembl ENSG00000198963 ENSMUSG00000036192 UniProt Q92753 Q58EY0 Q8R1B8 RefSeq (mRNA) NM_006914 NM_001365023 NM_001043354 NM_001289921 NM_146095 RefSeq (protein) NP_008845 NP_001351952 NP_001036819 NP_001276850 NP_666207 Location (UCSC) Chr 9: 74.5 – 74.69 Mb Chr 19: 18.91 – 19.09 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse RAR-related orphan receptor beta (ROR ...
Rs6265, also called Val66Met or G196A, is a gene variation, a single nucleotide polymorphism (SNP) in the BDNF gene that codes for brain-derived neurotrophic factor. Well over a hundred research studies have examined the polymorphism.
BDNF is a growth factor that has important roles in the survival and function of neurons in the central nervous system. The binding of BDNF to TrkB receptor causes many intracellular cascades to be activated, which regulate neuronal development and plasticity , long-term potentiation , and apoptosis .