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It is a type of organelle made up of two subunits – rough endoplasmic reticulum (RER), and smooth endoplasmic reticulum (SER). The endoplasmic reticulum is found in most eukaryotic cells and forms an interconnected network of flattened, membrane-enclosed sacs known as cisternae (in the RER), and tubular structures in the SER.
Secretory pathway diagram, including nucleus, endoplasmic reticulum and golgi apparatus. Nuclear membrane; Nuclear pore; Rough endoplasmic reticulum (rER)
Synthesis of proteins is by the rough endoplasmic reticulum (RER), and both the rough and smooth endoplasmic reticulum (SER) are involved in secretion of the proteins formed. [citation needed] The endoplasmic reticulum (ER) is involved in conjugation of proteins to lipid and carbohydrate moieties synthesized by, or modified within, the hepatocytes.
The Golgi apparatus plays a critical role in the modification of proteins through glycosylation, particularly N-linked glycosylation, which is a crucial process for the proper folding, stability, and function of many secretory and membrane-bound proteins. [6]
The Golgi apparatus (/ ˈ ɡ ɒ l dʒ i /), also known as the Golgi complex, Golgi body, or simply the Golgi, is an organelle found in most eukaryotic cells. [1] Part of the endomembrane system in the cytoplasm, it packages proteins into membrane-bound vesicles inside the cell before the vesicles are sent to their destination.
Nissl bodies occur in the somata and dendrites of neurons, though not in the axon or axon hillock. [6] They vary in size, shape, and intracellular location; they are most conspicuous in the motor neurons of the spinal cord and brainstem, where they appear as large, blocky assemblies. [5]
TAP-mediated peptide transport is a multistep process. The peptide-binding pocket is formed by TAP-1 and TAP-2. Association with TAP is an ATP-independent event, ‘in a fast bimolecular association step, peptide binds to TAP, followed by a slow isomerisation of the TAP complex’. [5]
RēR, the standard abbreviation for the label Recommended Records; Resident Evil: Revelations, a Capcom game; Respiratory exchange ratio, the ratio between the amount of carbon dioxide produced in metabolism and oxygen used; Rough endoplasmic reticulum, a type of endoplasmic reticulum protein-manufacturing ribosomes