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Oral medications used for the treatment of spasticity include: diazepam (Valium), dantrolene sodium, baclofen, tizanidine, clonidine, gabapentin, [59] [61] [62] and even cannabinoid-like compounds.³ The exact mechanism of these medications is not fully understood, but they are thought to act on neurotransmitters or neuromodulators within the ...
Hypertonia is a term sometimes used synonymously with spasticity and rigidity in the literature surrounding damage to the central nervous system, namely upper motor neuron lesions. [1] Impaired ability of damaged motor neurons to regulate descending pathways gives rise to disordered spinal reflexes , increased excitability of muscle spindles ...
It decreases pain in the first two weeks, [13] [14] peaking in the first few days, but has no proven benefit after two weeks. [13] [15] Since no benefit is proven beyond that, therapy should not be continued long-term. [12] It is the best-studied muscle relaxer. [13] It is not useful for spasticity due to neurologic conditions such as cerebral ...
Spasticity mostly occurs in disorders of the central nervous system (CNS) affecting the upper motor neurons in the form of a lesion, such as spastic diplegia, or upper motor neuron syndrome, and can also be present in various types of multiple sclerosis, where it occurs as a symptom of the progressively-worsening attacks on myelin sheaths and ...
Clonidine, sold under the brand name Catapres among others, is an α 2A-adrenergic receptor agonist [12] medication used to treat high blood pressure, ADHD, drug withdrawal (e.g., alcohol, opioids, or nicotine), menopausal flushing, diarrhea, spasticity, and certain pain conditions. [13]
Baclofen, sold under the brand name Lioresal among others, is a medication used to treat muscle spasticity, such as from a spinal cord injury or multiple sclerosis. [8] [9] It may also be used for hiccups and muscle spasms near the end of life, [9] and off-label to treat alcohol use disorder [10] [11] or opioid withdrawal symptoms. [12]
Antipsychotic medications These drugs are used to treat psychosis that can happen with schizophrenia, bipolar disorder, depression, and Alzheimer’s disease, according to the Cleveland Clinic .
Brunnstrom (1966, 1970) and Sawner (1992) also described the process of recovery following stroke-induced hemiplegia. The process was divided into a number of stages: Flaccidity (immediately after the onset) No "voluntary" movements on the affected side can be initiated; Spasticity appears; Basic synergy patterns appear
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