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Hydralazine is often used to treat hypertension in pregnancy, though, with either labetalol and/or methyldopa. [11] Hydralazine is commonly used in combination with isosorbide dinitrate for the treatment of congestive heart failure in black populations. This preparation, isosorbide dinitrate/hydralazine, was the first race-based prescription ...
Methyldopa, hydralazine, nifedipine, and labetalol are most commonly used for severe pregnancy hypertension. [ 7 ] The fetus is at increased risk for a variety of life-threatening conditions, including pulmonary hypoplasia (immature lungs).
Labetalol, hydralazine and nifedipine are commonly used antihypertensive agents for hypertension in pregnancy. [6] ACE inhibitors and angiotensin receptor blockers are contraindicated as they affect fetal development. [53] The goal of treatment of severe hypertension in pregnancy is to prevent cardiovascular, kidney, and cerebrovascular ...
Eclampsia is the onset of seizures (convulsions) in a woman with pre-eclampsia. [1] Pre-eclampsia is a hypertensive disorder of pregnancy that presents with three main features: new onset of high blood pressure, large amounts of protein in the urine or other organ dysfunction, and edema.
They are one of the three major causes of death in pregnancy (16%) along with post partum bleeding (13%) and puerperal infections (2%). [6] Hypertensive disorders during pregnancy, such as gestational hypertension, preeclampsia, and eclampsia, are a major contributor to maternal and fetal illness and death on a worldwide scale.
[31] [32] In any subsequent pregnancy, careful monitoring is necessary. A stress test or echocardiogram should be complete prior to a subsequent pregnancy. Where relapse occurs, conventional treatment should be resumed, including hydralazine with nitrates plus beta-blockers during pregnancy, or ACE-inhibitors plus beta-blockers following pregnancy.
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While hydralazine is the most well-known compound in this class, other related drugs such as dihydralazine also belong to the hydrazinophthalazine family and exhibit similar antihypertensive properties. These compounds have been in clinical use since the mid-20th century, with hydralazine being discovered in the 1940s and approved by the FDA in ...
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