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Clobetasol propionate was patented in 1968 and came into medical use in 1978. [13] It is available as a generic medication . [ 10 ] In 2022, it was the 156th most commonly prescribed medication in the United States, with more than 3 million prescriptions.
Long-term use of topical steroids can lead to secondary infection with fungus or bacteria (see tinea incognito), skin atrophy, telangiectasia (prominent blood vessels), skin bruising and fragility. [11] The use of the finger tip unit may be helpful in guiding how much topical steroid is required to cover different areas of the body.
Note the propionate groups at the C17α and C21α positions (top right corner). This is a list of corticosteroid esters , including esters of steroidal glucocorticoids and mineralocorticoids . [ 1 ] [ 2 ] [ 3 ]
Clobetasol is a synthetic glucocorticoid corticosteroid. A propionate ester of clobetasol, clobetasol propionate , has also been marketed, and is far more widely used in comparison. [ 2 ] [ 3 ]
ATC code D07 Corticosteroids, dermatological preparations is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes developed by the World Health Organization (WHO) for the classification of drugs and other medical products.
The following is a list of chemicals published as a requirement of Safe Drinking Water and Toxic Enforcement Act of 1986, commonly known as California Proposition 65, that are "known to the state to cause cancer or reproductive toxicity" as of January 3, 2020. [1]
Here are links to possibly useful sources of information about Clobetasol propionate. PubMed provides review articles from the past five years (limit to free review articles) The TRIP database provides clinical publications about evidence-based medicine. Other potential sources include: Centre for Reviews and Dissemination and CDC
[8] [23] The ointment and topical suspension formulation (Daivobet) were also approved in 2010 by the European Medicines Agency for the treatment of plaque psoriasis where it is possible to use a topical medication (ointment), and for the treatment of scalp psoriasis or mild to moderate plaque psoriasis on the body (topical suspension).
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