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It is ideally spatially unstructured and temporally unstructured, in a steady state defined by the rates of nutrient supply and bacterial growth. In comparison to batch culture, bacteria are maintained in exponential growth phase, and the growth rate of the bacteria is known. Related devices include turbidostats and auxostats.
The Monod equation is a mathematical model for the growth of microorganisms. It is named for Jacques Monod (1910–1976, a French biochemist, Nobel Prize in Physiology or Medicine in 1965), who proposed using an equation of this form to relate microbial growth rates in an aqueous environment to the concentration of a limiting nutrient.
For any fixed b not equal to 1 (e.g. e or 2), the growth rate is given by the non-zero time τ. For any non-zero time τ the growth rate is given by the dimensionless positive number b. Thus the law of exponential growth can be written in different but mathematically equivalent forms, by using a different base.
When calculating or discussing relative growth rate, it is important to pay attention to the units of time being considered. [ 2 ] For example, if an initial population of S 0 bacteria doubles every twenty minutes, then at time interval t {\displaystyle t} it is given by solving the equation:
As resources become more limited, the growth rate tapers off, and eventually, once growth rates are at the carrying capacity of the environment, the population size will taper off. [6] This S-shaped curve observed in logistic growth is a more accurate model than exponential growth for observing real-life population growth of organisms. [8]
This "Rule of 70" gives accurate doubling times to within 10% for growth rates less than 25% and within 20% for rates less than 60%. Larger growth rates result in the rule underestimating the doubling time by a larger margin. Some doubling times calculated with this formula are shown in this table. Simple doubling time formula:
One of the most important features of chemostats is that microorganisms can be grown in a physiological steady state under constant environmental conditions. In this steady state, growth occurs at a constant specific growth rate and all culture parameters remain constant (culture volume, dissolved oxygen concentration, nutrient and product concentrations, pH, cell density, etc.).
Moreover, the function makes use of initial growth rate, which is commonly seen in populations of bacterial and cancer cells, which undergo the log phase and grow rapidly in numbers. Despite its popularity, the function initial rate of tumor growth is difficult to predetermine given the varying microcosms present with a patient, or varying ...