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C-reactive protein (CRP) is an annular (ring-shaped) pentameric protein found in blood plasma, whose circulating concentrations rise in response to inflammation. It is an acute-phase protein of hepatic origin that increases following interleukin-6 secretion by macrophages and T cells .
Some act to destroy or inhibit growth of microbes, e.g., C-reactive protein, mannose-binding protein, [3] complement factors, ferritin, ceruloplasmin, serum amyloid A and haptoglobin. Others give negative feedback on the inflammatory response, e.g. serpins. Alpha 2-macroglobulin and coagulation factors affect coagulation, mainly stimulating it.
It is also widely known that cholesterol values are a biomarker and risk indicator for coronary and vascular disease, and that C-reactive protein is a marker for inflammation. Biomarkers are useful in a number of ways, including measuring the progress of disease, evaluating the most effective therapeutic regimes for a particular cancer type ...
I think these sections need combining and rearranging. CRP is mainly used as a non-specific marker of inflammation (e.g. see here), but the article currently doesn't reflect that - it starts talking about specific conditions where it's less important, like cancer and cardiovascular disease. Arripay 23:08, 4 August 2013 (UTC)
Chronic systemic inflammation (SI) is the result of release of pro-inflammatory cytokines from immune-related cells and the chronic activation of the innate immune system.It can contribute to the development or progression of certain conditions such as cardiovascular disease, cancer, diabetes mellitus, chronic kidney disease, non-alcoholic fatty liver disease, autoimmune and neurodegenerative ...
C-reactive protein (CRP) is an acute phase protein. Therefore, it is a better marker for acute phase reaction than ESR. While ESR and CRP generally together correlate with the degree of inflammation, this is not always the case and results may be discordant [9] in 12.5% of the cases. [7]
Dan Skillings Jr. scored 17 points and Jizzle James added 14 as No. 19 Cincinnati ended No. 22 Dayton's five-game winning streak 66-59 on Friday night. Simas Lukosius added 13 for the Bearcats (9 ...
Inflammation also is characterized by high systemic levels of acute-phase proteins. In acute inflammation, these proteins prove beneficial; however, in chronic inflammation, they can contribute to amyloidosis. [9] These proteins include C-reactive protein, serum amyloid A, and serum amyloid P, which cause a range of systemic effects including: [9]