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Candidiasis is a fungal infection due to any species of the genus Candida (a yeast). [4] When it affects the mouth, in some countries it is commonly called thrush. [3] Signs and symptoms include white patches on the tongue or other areas of the mouth and throat. [3]
Oral candidiasis (Acute pseudomembranous candidiasis), which is also known as oral thrush, among other names, [1] is candidiasis that occurs in the mouth. That is, oral candidiasis is a mycosis (yeast/fungal infection) of Candida species on the mucous membranes of the mouth .
An estimated 1.6 million deaths from fungal disease were reported in 2017. [30] The figure has been rising, with an estimated 1.7 million deaths from fungal disease reported in 2020. [12] Fungal infections also constitute a significant cause of illness and mortality in children. [31]
Treatment for thrush is considered to have failed if the symptoms do not clear within 7–14 days. There are a number of reasons for treatment failure. For example, if the infection is a different kind, such as bacterial vaginosis (the most common cause of abnormal vaginal discharge), rather than thrush.
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Current effective treatments include anti-fungal drugs and, for long-term remissions, restoration of cellular immunity. [ 6 ] Patients with autosomal-dominant mucocutaneous candidiasis may be at risk for epidermoid esophageal cancer due to the nitrosamine compounds produced by chronic candida infections.
The current first-line treatment is fluconazole, 200 mg on the first day, followed by daily dosing of 100 mg for at least 21 days total. Treatment should continue for 14 days after relief of symptoms. Other therapy options include: Nystatin is an effective treatment for mild esophageal candidiasis. [2]
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