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The WHO classification of tumours of the central nervous system is a World Health Organization Blue Book that defines, describes and classifies tumours of the central nervous system (CNS). Currently, as of 2023, clinicians are using the 5th edition, which incorporates recent advances in molecular pathology. [ 1 ]
The concept of grading of the tumors of the central nervous system, agreeing for such the regulation of the "progressiveness" of these neoplasias (from benign and localized tumors to malignant and infiltrating tumors), dates back to 1926 and was introduced by P. Bailey and H. Cushing, [1] in the elaboration of what turned out the first systematic classification of gliomas.
Leslie Sobin edited the first edition, published from 1967 to 1981, as the International Histological Classification of Tumors series. [9] [10] Sobin edited a second edition of 25 volumes, published by Springer between 1982 and 2002. [9] In 1993 the WHO approved a concise classification of tumours affecting the central nervous system. [11]
Oligodendrogliomas are a type of glioma that are believed to originate from the oligodendrocytes of the brain or from a glial precursor cell. They occur primarily in adults (9.4% of all primary brain and central nervous system tumors) but are also found in children (4% of all primary brain tumors).
The 2007 WHO Classification of Tumors of the Central Nervous System [37] was the last classification mainly based on microscopy features. The new 2016 WHO Classification of Tumors of the Central Nervous System [38] was a paradigm shift: some of the tumors were defined also by their genetic composition as well as their cell morphology.
The International Classification of Diseases for Oncology (ICD-O) is a domain-specific extension of the International Statistical Classification of Diseases and Related Health Problems for tumor diseases. This classification is widely used by cancer registries. It is currently in its third revision (ICD-O-3). ICD-10 includes a list of ...
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Primary central nervous system lymphoma (PCNSL), also termed primary diffuse large B-cell lymphoma of the central nervous system (DLBCL-CNS), [2] is a primary intracranial tumor appearing mostly in patients with severe immunodeficiency (typically patients with AIDS).