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Amisulpride, sold under the brand names Solian and Barhemsys, is a medication used in the treatment of schizophrenia, acute psychotic episodes, depression, and nausea and vomiting. [ 9 ] [ 6 ] It is specifically used at lower doses intravenously to prevent and treat postoperative nausea and vomiting ; [ 9 ] at low doses by mouth to treat ...
SEP-4199, also known as non-racemic amisulpride, is a non-racemic form of amisulpride which is under development for the treatment of bipolar depression. [ 1 ] [ 2 ] [ 3 ] It is taken by mouth . [ 1 ]
A dosage of 50 mg/day N-methylamisulpride has been found to achieve 60 to 80% occupancy of the dopamine D 2 receptor, whereas 300 to 400 mg/day amisulpride achieved around 70% occupancy and doses of 630 to 910 mg/day amisulpride achieved 70 to 80% occupancy of the receptor. [4] [6] Amisulpride has been associated with QT prolongation.
As Americans are increasingly reaching for pharmaceutical solutions for depression—about one in eight U.S. adults takes antidepressants—scientists have been innovating novel treatments for it.
This is a list of investigational antidepressants, or drugs that are currently under development for clinical use in the treatment of depression but are not yet approved. Specific indications include major depressive disorder, treatment-resistant depression, dysthymia, bipolar depression, and postpartum depression, among others.
Avicii was found dead in the afternoon hours of April 20, 2018, according to a statement from his rep. His tragic death came two years after he announced his retirement from touring in March 2016.
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