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The International Agency for Research on Cancer (IARC) rendered PCBs as definite carcinogens in humans. According to the U.S. Environmental Protection Agency (EPA), PCBs cause cancer in animals and are probable human carcinogens. [4] Moreover, because of their use as a coolant in electric transformers, PCBs still persist in built environments ...
Ortho-PCBs may alter hormone regulation through disruption of the thyroid hormone transport by binding to transthyretin. [8] Coplanar PCBs are similar to dioxins and furans, both bind to the aryl hydrocarbon receptor (AhR) in organisms and may exert dioxin-like effects, in addition to the effects shared with non-coplanar PCBs.
Dioxins build up primarily in fatty tissues over time (bioaccumulation), so even small exposures may eventually reach dangerous levels. In 1994, the US EPA reported that dioxins are a probable carcinogen, but noted that non-cancer effects (reproduction and sexual development, immune system) may pose a greater threat to human health.
Oct. 5, 2023: NC State contacted the North Carolina Department of Health and Human Services “regarding concerns about breast cancer cases in people who spent time in Poe Hall,” NCDHHS ...
No harmful levels of carcinogenic PCBs were found inside the missile launch facilities at F.E. Warren Air Force base in Wyoming, the service said Tuesday, as it looks for possible causes for ...
PCB contamination in humans may come from drinking the contaminated water, absorption through the skin, eating contaminated aquatic life, and/or inhaling volatilized PCBs. PCB contamination is especially dangerous for pregnant and nursing women. The contamination can reach the fetus and potentially cause birth defects.
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Ionizing radiation may be used to treat other cancers, but this may, in some cases, induce a second form of cancer. [74] Radiation can cause cancer in most parts of the body, in all animals, and at any age, although radiation-induced solid tumors usually take 10–15 years, and can take up to 40 years, to become clinically manifest, and ...