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PSA velocity (PSAV) was found in a 2008 study to be more useful than the PSA doubling time (PSA DT) to help identify those men with life-threatening disease before start of treatment. [ 63 ] Men who are known to be at risk for prostate cancer, and who decide to plot their PSA values as a function of time (i.e., years), may choose to use a semi ...
Vickers is known for his research into prostate cancer screening. [6] In 2011, he published a study which found that PSA velocity—the change in the blood level of prostate-specific antigen (PSA)--was not a more accurate predictor of prostate cancer than comparing PSA levels to a specific threshold. [7]
A further study, the NHS Comparison Arm for ProtecT (CAP), as part of the Prostate testing for cancer and Treatment (ProtecT) study, randomized GP practices with 460,000 men aged 50–69 at centers in 9 cities in Britain from 2001–2005 to usual care or prostate cancer screening with PSA (biopsy if PSA ≥ 3). [65]
The LNCaP (Lymph Node Carcinoma of the Prostate) cell line was established from a metastatic lesion of human prostatic adenocarcinoma.The LNCaP cells grow readily in vitro (up to 8 x 10 5 cells/sq cm; doubling time, 60 hr), form clones and are highly resistant to human fibroblast interferon. [1]
The notion of doubling time dates to interest on loans in Babylonian mathematics. Clay tablets from circa 2000 BCE include the exercise "Given an interest rate of 1/60 per month (no compounding), come the doubling time." This yields an annual interest rate of 12/60 = 20%, and hence a doubling time of 100% growth/20% growth per year = 5 years.
In science, e-folding is the time interval in which an exponentially growing quantity increases or decreases by a factor of e; [1] it is the base-e analog of doubling time. This term is often used in many areas of science, such as in atmospheric chemistry, medicine, theoretical physics, and cosmology.
When the Womersley number is large (around 10 or greater), it shows that the flow is dominated by oscillatory inertial forces and that the velocity profile is flat. When the Womersley parameter is low, viscous forces tend to dominate the flow, velocity profiles are parabolic in shape, and the center-line velocity oscillates in phase with the ...
Pressure swing adsorption (PSA) is a technique used to separate some gas species from a mixture of gases (typically air) under pressure according to the species' molecular characteristics and affinity for an adsorbent material.
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