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Iron overload (also known as haemochromatosis or hemochromatosis) is the abnormal and increased accumulation of total iron in the body, leading to organ damage. [1] The primary mechanism of organ damage is oxidative stress, as elevated intracellular iron levels increase free radical formation via the Fenton reaction.
Haemochromatosis is protean in its manifestations, i.e., often presenting with signs or symptoms suggestive of other diagnoses that affect specific organ systems.Many of the signs and symptoms below are uncommon, and most patients with the hereditary form of haemochromatosis do not show any overt signs of disease nor do they have premature morbidity, if they are diagnosed early, but, more ...
Celsus signs of inflammation: Aulus Cornelius Celsus: various: inflammation: 1. Rubor (redness) 2. Tumor (swelling)3. Calor (heat) 4. Dolor (pain) Chaddock reflex: Charles Gilbert Chaddock: neurology: pyramidal lesions, corticospinal tract lesions: extension of big toe with stimulation of skin over lateral malleolus Chadwick sign: James Read ...
Hypochromic anemia occurs in patients with hypochromic microcytic anemia with iron overload. The condition is autosomal recessive and is caused by mutations in the SLC11A2 gene. The condition prevents red blood cells from accessing iron in the blood, which causes anemia that is apparent at birth. It can lead to pallor, fatigue, and slow growth.
Schamberg's disease is caused by leaky blood vessels near the surface of the skin, capillaries, which allow red blood cells to slip through into the skin. [3] The red blood cells in the skin then fall apart and release their iron, which is released from hemoglobin. [3] The iron causes a rust color and this accounts for the orange tint of the ...
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Koilonychia, also known as spoon nails, [1]: 782 is a nail disease that can be a sign of hypochromic anemia, especially iron-deficiency anemia. [2]: 656 [3] It refers to abnormally thin nails (usually of the hand) which have lost their convexity, becoming flat or even concave in shape.