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Like many other medical conditions, obesity is the result of an interplay between environmental and genetic factors. [2] [3] Studies have identified variants in several genes that may contribute to weight gain and body fat distribution, although only in a few cases are genes the primary cause of obesity. [4] [5]
The extreme endpoint of this distribution are the so-called 'monogenic' obesities where most of the impact on body weight can be tied to a mutation in a single gene that runs in a single family. The classic example of such a genetic effect is the presence of mutations in the leptin gene. [29]
“This means that if someone with small fat cells does gain weight, it may not raise their risk of conditions such as type 2 diabetes and high blood pressure as much as if they had large fat ...
Genetic load may increase when deleterious mutations, migration, inbreeding, or outcrossing lower mean fitness. Genetic load may also increase when beneficial mutations increase the maximum fitness against which other mutations are compared; this is known as the substitutional load or cost of selection .
Weight gain is an increase in body weight. This can involve an increase in muscle mass , fat deposits , excess fluids such as water or other factors. Weight gain can be a symptom of a serious medical condition.
Hormones are involved in regulating body weight and the ability to achieve weight loss. Especially for women, they fluctuate throughout your menstrual cycle and during various life stages, like ...
Genetic load is the difference between the fitness of an average genotype in a population and the fitness of some reference genotype, ...
Weight gain, on the other hand, may reduce the diversity of healthy microorganisms in your body. Below we’ll take a closer look at what gut health really means and how weight loss and weight ...