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The image at the left is a crystal structure of the double-d fragment from human fibrin with two bound ligands. The experimental method used to obtain the image was X-ray diffraction, and it has a resolution of 2.30 Å. The structure is mainly made up of single alpha helices shown in red and beta sheets shown in yellow.
2243 14161 Ensembl ENSG00000171560 ENSMUSG00000028001 UniProt P02671 E9PV24 RefSeq (mRNA) NM_000508 NM_021871 NM_001111048 NM_010196 RefSeq (protein) NP_000499 NP_068657 NP_001104518 NP_034326 Location (UCSC) Chr 4: 154.58 – 154.59 Mb Chr 3: 82.93 – 82.94 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Fibrinogen alpha chain is a protein that in humans is encoded by the FGA gene ...
Fibrinogen is made and secreted into the blood primarily by liver hepatocyte cells. Endothelium cells are also reported to make small amounts of fibrinogen, but this fibrinogen has not been fully characterized; blood platelets and their precursors, bone marrow megakaryocytes, while once thought to make fibrinogen, are now known to take up and store but not make the glycoprotein.
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The fibrinopeptides, fibrinopeptide A (FpA) and fibrinopeptide B (FpB), are peptides which are located in the central region of the fibrous glycoprotein fibrinogen (factor I) and are cleaved by the enzyme thrombin (factor IIa) to convert fibrinogen into covalently-linked fibrin (factor IA) monomers.
Fibrous proteins consist of many families including keratin, collagen, elastin, fibrin or spidroin. Collagen is the most abundant of these proteins which exists in vertebrate connective tissue including tendon, cartilage, and bone. [2]
2266 99571 Ensembl ENSG00000171557 ENSMUSG00000033860 UniProt P02679 Q8VCM7 RefSeq (mRNA) NM_021870 NM_000509 NM_133862 NM_001317105 RefSeq (protein) NP_000500 NP_068656 NP_001304034 NP_598623 Location (UCSC) Chr 4: 154.6 – 154.61 Mb Chr 3: 82.92 – 82.92 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Fibrinogen gamma chain, also known as fibrinogen gamma gene (FGG), is a human ...
Primal Pictures is a business established in 1991 that provides 3D graphic renderings of human anatomy, built using real scan data from the Visible Human Project, for use by healthcare students, educators, and medical professionals. It operates the Anatomy.tv online platform. [1]