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  2. Troponin I - Wikipedia

    en.wikipedia.org/wiki/Troponin_I

    Troponin I is a biomarker that responds to treatment interventions. Reductions in troponin I levels proved to reduce the risk of future CVD. [23] [24] [25] High sensitive troponin I used as a screening tool to assess a person's cardiovascular risk and has the potential to reduce the growing cost burden of the healthcare system. [26]

  3. Cardiac marker - Wikipedia

    en.wikipedia.org/wiki/Cardiac_marker

    Sensitivity and specificity Approximate peak Description Troponin test: The most sensitive and specific test for myocardial damage. Because it has increased specificity compared with CK-MB, troponin is composed of 3 proteins- Troponin C, Cardic troponin I, and Cardiac troponin T. Troponin I especially has a high affinity for myocardial injury ...

  4. Troponin - Wikipedia

    en.wikipedia.org/wiki/Troponin

    Troponin T (blue) anchors the complex on tropomyosin. Troponin is found in both skeletal muscle and cardiac muscle, but the specific versions of troponin differ between types of muscle. The main difference is that the TnC subunit of troponin in skeletal muscle has four calcium ion-binding sites, whereas in cardiac muscle there are only three.

  5. Likelihood ratios in diagnostic testing - Wikipedia

    en.wikipedia.org/wiki/Likelihood_ratios_in...

    They use the sensitivity and specificity of the test to determine whether a test result usefully changes the probability that a condition (such as a disease state) exists. The first description of the use of likelihood ratios for decision rules was made at a symposium on information theory in 1954. [ 1 ]

  6. Sensitivity and specificity - Wikipedia

    en.wikipedia.org/wiki/Sensitivity_and_specificity

    The 'worst-case' sensitivity or specificity must be calculated in order to avoid reliance on experiments with few results. For example, a particular test may easily show 100% sensitivity if tested against the gold standard four times, but a single additional test against the gold standard that gave a poor result would imply a sensitivity of ...

  7. Troponin T - Wikipedia

    en.wikipedia.org/wiki/Troponin_t

    Troponin T binds to tropomyosin and helps position it on actin, [2] and together with the rest of the troponin complex, modulates contraction of striated muscle. [3] The cardiac subtype of troponin T is especially useful in the laboratory diagnosis of heart attack because it is released into the blood-stream when damage to heart muscle occurs. [4]

  8. Revised Cardiac Risk Index - Wikipedia

    en.wikipedia.org/wiki/Revised_Cardiac_Risk_Index

    The Revised Cardiac Risk Index (RCRI) is a tool used to estimate a patient's risk of perioperative cardiac complications. The RCRI and similar clinical prediction tools are derived by looking for an association between preoperative variables (e.g., patient's age, type of surgery, comorbid diagnoses, or laboratory data) and the risk for cardiac complications in a cohort of surgical patients ...

  9. Pre- and post-test probability - Wikipedia

    en.wikipedia.org/wiki/Pre-_and_post-test_probability

    It can be seen from the length of the arrows that, at low pre-test probabilities, a positive test gives a greater change in absolute probability than a negative test (a property that is generally valid as long as the specificity isn't much higher than the sensitivity). Similarly, at high pre-test probabilities, a negative test gives a greater ...