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Cimetidine, sold under the brand name Tagamet among others, is a histamine H 2 receptor antagonist that inhibits stomach acid production. [ 1 ] [ 9 ] [ 10 ] It is mainly used in the treatment of heartburn and peptic ulcers .
This is often called linear pharmacokinetics, as the change in concentration over time can be expressed as a linear differential equation =. Assuming a single IV bolus dose resulting in a concentration C initial {\displaystyle C_{\text{initial}}} at time t = 0 {\displaystyle t=0} , the equation can be solved to give C = C initial × e − k el ...
In pharmacology, the international unit (IU) is a unit of measurement for the effect or biological activity of a substance, for the purpose of easier comparison across similar forms of substances. International units are used to quantify vitamins and biologics ( hormones , some medications , vaccines , blood products and similar biologically ...
First-pass metabolism may occur in the liver (for propranolol, lidocaine, clomethiazole, and nitroglycerin) or in the gut (for benzylpenicillin and insulin). [4] The four primary systems that affect the first pass effect of a drug are the enzymes of the gastrointestinal lumen, [5] gastrointestinal wall enzymes, [6] [7] [8] bacterial enzymes [5] and hepatic enzymes.
The term "fine chemicals" was in use as early as 1908. [1] The emergence of the fine chemical industry as a distinct entity dates to the late 1970s, when the overwhelming success of the histamine H 2 receptor antagonists Tagamet (cimetidine) and Zantac (ranitidine hydrochloride) created a strong demand for advanced organic chemicals used in their manufacture.
Antihistamines are drugs which treat allergic rhinitis, common cold, influenza, and other allergies. [1] Typically, people take antihistamines as an inexpensive, generic (not patented) drug that can be bought without a prescription and provides relief from nasal congestion, sneezing, or hives caused by pollen, dust mites, or animal allergy with few side effects. [1]
Nizatidine was developed by Eli Lilly, and was first marketed in 1988. [3] It is considered to be equipotent with ranitidine and differs by the substitution of a thiazole ring in place of the furan ring in ranitidine.
The TU (for time unit) is a unit of time defined as 1024 μs for use in engineering. The svedberg is a time unit used for sedimentation rates (usually of proteins). It is defined as 10 −13 seconds (100 fs). The galactic year, based on the rotation of the galaxy and usually measured in million years. [2]
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