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Minoxidil, applied topically, is widely used for the treatment of hair loss. It may be effective in helping promote hair growth in both men and women with androgenic alopecia. [20] [21] About 40% of men experience hair regrowth after 3–6 months. [22] It is the only topical product that is FDA approved in America for androgenic hair loss. [20]
Finasteride is most effective on the crown but can reduce hair loss in all areas of the scalp. [27] [28] Finasteride has also been tested for pattern hair loss in women; however, the results were no better than placebo. [29] Finasteride is less effective in the treatment of scalp hair loss than dutasteride. [30] [31]
It was formerly under investigation by ProStrakan (previously ProSkelia and Strakan) for potential use as a topical treatment for androgen-dependent conditions including acne, pattern hair loss, [1] and excessive hair growth. [2] [3] [1] The compound is similar in structure to the NSAA RU-58642 but contains a different side-chain. [4]
Dutasteride is approved for the treatment of male androgenetic alopecia in South Korea and Japan at a dosage of 0.5 mg per day. [6] [17] Several studies have found it to induce hair regrowth in men more rapidly and to a greater extent than even the highest approved dosage of finasteride.
Hair loss, also known as alopecia or baldness, refers to a loss of hair from part of the head or body. [2] Typically at least the head is involved. [4] The severity of hair loss can vary from a small area to the entire body. [7] Inflammation or scarring is not usually present. [4] Hair loss in some people causes psychological distress. [3]
Minoxidil is a medication used for the treatment of high blood pressure and pattern hair loss. [ 5 ] [ 6 ] [ 7 ] It is an antihypertensive and a vasodilator . [ 10 ] It is available as a generic medication by prescription in oral tablet form and over the counter as a topical liquid or foam.
Aside from pattern hair loss, the drugs are also useful in the treatment of hirsutism and can greatly reduce facial and body hair growth in women with the condition. [ 35 ] [ 16 ] 5α-Reductase inhibitors are overall well tolerated and show a low incidence of adverse effects . [ 36 ]
A second study suggested carcinogenic effects were unlikely and that the primary risk would be associated with developmental effects due to exposure in pregnancy and neonates. [108] Two businessmen who knowingly sold the contaminated feed ingredient received two-year suspended sentences for their role in the crisis.
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