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Vitamin D compounds, specifically cholecalciferol (D3) and ergocalciferol (D2), are used in rodenticides due to their ability to induce hypercalcemia, a condition characterized by elevated calcium levels in the blood. This overdose leads to organ failure and is pharmacologically similar to vitamin D's toxic effects in humans.
Low levels of vitamin D in pregnancy are associated with gestational diabetes, pre-eclampsia, and small (for gestational age) infants. [105] Although taking vitamin D supplements during pregnancy raises blood levels of vitamin D in the mother at term, [106] the full extent of benefits for the mother or baby is unclear.
Calcitriol is a hormone and the active form of vitamin D, normally made in the kidney. [ 8 ][ 9 ][ 10 ] It is also known as 1,25-dihydroxycholecalciferol. It binds to and activates the vitamin D receptor in the nucleus of the cell, which then increases the expression of many genes. [ 11 ]
Signs of vitamin D deficiency. Fatigue. Mood changes. Muscle pain and weakness. Reduced immune function. Increased inflammation. Frequent infections. Rickets (in children)
Mapping of several bone diseases onto levels of vitamin D (calcidiol) in the blood [6] Normal bone vs. osteoporosis. Vitamin D deficiency is typically diagnosed by measuring the concentration of the 25-hydroxyvitamin D in the blood, which is the most accurate measure of stores of vitamin D in the body.
An estimated third of Americans 60 and older take the supplements and more than 10 million blood tests for vitamin D levels are performed annually -- despite years of controversy over whether the ...
A vitamin D blood-concentration standard for diagnosing hypovitaminosis D does not exist. In the past, hypovitaminosis D was defined by blood concentrations lower than 20 ng/mL. [ 6 ] However, in more recent literature many researchers have considered 30 ng/mL to be an insufficient concentration of vitamin D. [ 6 ] Subnormal levels of vitamin D ...
Calcifediol is strongly bound in blood by the vitamin D-binding protein. [5] Measurement of serum calcifediol is the usual test performed to determine a person's vitamin D status, to show vitamin D deficiency or sufficiency. [4] [5] Calcifediol is available as an oral medication in some countries to supplement vitamin D status. [4] [6] [7]