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Actinic keratosis (AK), sometimes called solar keratosis or senile keratosis, [1] [2] is a pre-cancerous [3] area of thick, scaly, or crusty skin. [ 4 ] [ 5 ] Actinic keratosis is a disorder ( -osis ) of epidermal keratinocytes that is induced by ultraviolet (UV) light exposure ( actin- ).
Solar purpura (also known as "Actinic purpura," and "Senile purpura") is a skin condition characterized by large, sharply outlined, 1- to 5-cm, dark purplish-red ecchymoses appearing on the dorsa of the forearms and less often the hands. [1] The condition is most common in elderly people of European descent. It is caused by sun-induced damage ...
Tirbanibulin, sold under the brand name Klisyri, is a medication used for the treatment of actinic keratosis (AK) on the face or scalp. [4][5][6] It functions by inhibiting both tubulin polymerization and Src kinase signaling. [7] It is potentially effective in impeding the development of squamous cell carcinoma in situ.
Actinic keratosis treatments. Treatment may include liquid nitrogen, scraping, chemical peels or other therapies to remove the actinic keratosis. Read more about actinic keratosis and how to treat it.
Dermatology. Actinic cheilitis is cheilitis (lip inflammation) caused by long term sunlight exposure. Essentially it is a burn, [2] and a variant of actinic keratosis which occurs on the lip. [5] It is a premalignant condition, [6] as it can develop into squamous cell carcinoma (a type of mouth cancer).
SCC of the skin begins as a small nodule and as it enlarges the center becomes necrotic and sloughs and the nodule turns into an ulcer, and generally are developed from an actinic keratosis. Once keratinocytes begin to grow uncontrollably, they have the potential to become cancerous and produce cutaneous squamous-cell carcinoma. [22]
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