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  2. Biochemical switches in the cell cycle - Wikipedia

    en.wikipedia.org/wiki/Biochemical_switches_in...

    In the absence of coherent gene expression, cells take longer to exit G1 and a significant fraction even arrest before S phase, highlighting the importance of positive feedback in sharpening the G1/S switch. The G1/S cell cycle checkpoint controls the passage of eukaryotic cells from the first gap phase, G1, into the DNA synthesis phase, S.

  3. Code-break procedure - Wikipedia

    en.wikipedia.org/wiki/Code-break_procedure

    A code-break procedure is a set of rules which determine when planned unblinding should occur in a blinded experiment. FDA guidelines recommend that sponsors of blinded trials include a code-break procedure in their standard operating procedure .

  4. Anaphase-promoting complex - Wikipedia

    en.wikipedia.org/wiki/Anaphase-promoting_complex

    Anaphase-promoting complex (also called the cyclosome or APC/C) is an E3 ubiquitin ligase that marks target cell cycle proteins for degradation by the 26S proteasome. The APC/C is a large complex of 11–13 subunit proteins , including a cullin ( Apc2 ) and RING ( Apc11 ) subunit much like SCF .

  5. APC/C activator protein CDH1 - Wikipedia

    en.wikipedia.org/wiki/APC/C_activator_protein_CDH1

    Cdh1 plays a pivotal role in controlling cell division at the end of mitosis and in the subsequent G1 phase of cell cycle: By recognizing and binding proteins (like mitotic cyclins) which contain a destruction box (D-box) and an additional degradation signal (KEN box), Cdh1 recruits them in a C-box-dependent mechanism to the APC for ubiquination and subsequent proteolysis.

  6. Cell engineering - Wikipedia

    en.wikipedia.org/wiki/Cell_engineering

    Cell engineering is the purposeful process of adding, deleting, or modifying genetic sequences in living cells to achieve biological engineering goals such as altering cell production, changing cell growth and proliferation requirements, adding or removing cell functions, and many more.

  7. Cellosaurus - Wikipedia

    en.wikipedia.org/wiki/Cellosaurus

    Its scope includes immortalised cell lines, naturally immortal cell lines (example: embryonic stem cells) and finite life cell lines when those are distributed and used widely. The Cellosaurus provides a wealth of manually curated information; for each cell line it lists a recommended name, synonyms and the species of origin.

  8. Genetic code - Wikipedia

    en.wikipedia.org/wiki/Genetic_code

    The genetic code is the set of rules used by living cells to translate information encoded within genetic material (DNA or RNA sequences of nucleotide triplets or codons) into proteins. Translation is accomplished by the ribosome , which links proteinogenic amino acids in an order specified by messenger RNA (mRNA), using transfer RNA (tRNA ...

  9. The Code Breaker - Wikipedia

    en.wikipedia.org/wiki/The_Code_Breaker

    The Code Breaker: Jennifer Doudna, Gene Editing, and the Future of the Human Race is a non-fiction book authored by American historian and journalist Walter Isaacson. Published in March 2021 by Simon & Schuster , it is a biography of Jennifer Doudna , the winner of the 2020 Nobel Prize in Chemistry for her work on the CRISPR system of gene ...