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Tuberculosis generally affects the lungs, but it can also affect other parts of the body. [1] Most infections show no symptoms, in which case it is known as latent tuberculosis. [1] Around 10% of latent infections progress to active disease that, if left untreated, kill about half of those affected. [1]
M. tuberculosis can also grow on the lipid cholesterol as a sole source of carbon, and genes involved in the cholesterol use pathway(s) have been validated as important during various stages of the infection lifecycle of M. tuberculosis, especially during the chronic phase of infection when other nutrients are likely not available. [47]
Most people affected by TB do not have symptoms, and the disease is not active. This is called latent tuberculosis. [1] However, about 10% of latent infections progress to active disease, which, if left untreated, kills about half of those affected. [1]
According to the World Health Organization’s (WHO) Global Tuberculosis Report 2024, roughly 10.8 million people “fell ill” with the bacterial infection in 2023. “The continued rise ...
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The U.N. health agency said more than 10 million people worldwide were sickened by tuberculosis in 2021, a 4.5% rise from the year before. WHO said about 450,000 cases involved people infected ...
Persons with HIV and latent tuberculosis have a 10% chance of developing active tuberculosis every year. "HIV infection is the greatest known risk factor for the progression of latent M. tuberculosis infection to active TB. In many African countries, 30–60% of all new TB cases occur in people with HIV, and TB is the leading cause of death ...
Aspergilloma in an old tuberculosis cavity; healed, calcified tuberculous lesions are also present towards the right of the image Healed tuberculous cavity, where the entire left lung is destroyed. Post-tuberculosis lung disease (PTLD) is ongoing lung disease that is caused by tuberculosis (TB) but persists after the infection is cured. [1]