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4-Methylpyridine is both isolated from coal tar and is synthesized industrially. It forms via the reaction of acetaldehyde and ammonia in the presence of an oxide catalyst. The method also affords some 2-methylpyridine. 4-Methylpyridine is of little intrinsic value but is a precursor to other commercially significant species, often of medicinal ...
Piperidine is also commonly used as a base for the deprotection of Fmoc-amino acids used in solid-phase peptide synthesis. Piperidine is listed as a Table II precursor under the United Nations Convention Against Illicit Traffic in Narcotic Drugs and Psychotropic Substances due to its use (peaking in the 1970s) in the clandestine manufacture of ...
bedinvetmab - nerve growth factor inhibitor monoclonal antibody used for osteoarthritis in dogs; benazepril – ACE-inhibitor used in heart failure, hypertension, chronic kidney failure and protein-losing nephropathy; bethanechol – stimulates bladder contractions, tranquilizer, makes the patient feel no pain; bexagliflozin - oral antidiabetic ...
Pethidinic acid (meperidinic acid, pethidine intermediate C) is a 4-phenyl piperidine derivative that is both a metabolite of and a precursor to pethidine (meperidine). [2] [3] It is scheduled by UN Single Convention on Narcotic Drugs. It is a Schedule II Narcotic controlled substance in the United States and has an ACSCN of 9234.
This amine is used in chemistry as a hindered base (hindered amine). Although TMP finds limited use per se, its derivatives are a mainstay of hindered amine light stabilizers . TMP is the starting material for an even stronger base, lithium tetramethylpiperidide and the radical species TEMPO .
Chemical structure of 4-phenylpiperidine. Phenylpiperidines are chemical compounds with a phenyl moiety directly attached to piperidine . Of particular interest are a variety of derivatives of 4-phenylpiperidine , which have pharmacological effects including morphine -like activity [ 1 ] or other central nervous system effects.
4-Piperidone is an organic compound with the molecular formula OC(CH 2) 4 NH. It can be viewed as a derivative of piperidine. 4-Piperidone is used as an intermediate in the manufacture of chemicals and pharmaceutical drugs. Substituted and dehydro derivatives of 4-piperidinone are intermediates in alkaloid syntheses. [1]
PCE was reported in 1953 and PCMo (4-(1-phenyl-cyclohexyl)-morpholine [1] see chart below for figure) in 1954, with PCMo described as a potent sedative. [2] Arylcyclohexylamine anesthetics were intensively investigated at Parke-Davis , beginning with the 1956 studies of PCP and later the related compound ketamine . [ 2 ]
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