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  2. Sequestrum - Wikipedia

    en.wikipedia.org/wiki/Sequestrum

    infection in the bone leads to an increase in intramedullary pressure due to inflammatory exudates; the periosteum becomes stripped from the ostium, leading to vascular thrombosis; bone necrosis follows due to lack of blood supply; sequestra are formed; The sequestra are surrounded by sclerotic bone which is relatively avascular (without a ...

  3. Scleroderma - Wikipedia

    en.wikipedia.org/wiki/Scleroderma

    Graft-versus-host disease is an autoimmune condition that occurs as a result of bone-marrow transplants in which the immune cells from the transplanted bone marrow attack the host's body. Mycosis fungoides is a type of cutaneous T cell lymphoma , a rare cancer that causes rashes all over the body.

  4. Myelodysplastic syndrome - Wikipedia

    en.wikipedia.org/wiki/Myelodysplastic_syndrome

    Indicators of a poor prognosis: Advanced age; severe neutropenia or thrombocytopenia; high blast count in the bone marrow (20–29%) or blasts in the blood; Auer rods; absence of ringed sideroblasts; abnormal localization or immature granulocyte precursors in bone marrow section; completely or mostly abnormal karyotypes, or complex marrow ...

  5. Osteosclerosis - Wikipedia

    en.wikipedia.org/wiki/Osteosclerosis

    Osteosclerosis is a disorder characterized by abnormal hardening of bone and an elevation in bone density. It may predominantly affect the medullary portion and/or cortex of bone. Plain radiographs are a valuable tool for detecting and classifying osteosclerotic disorders. [1] [2] It can manifest in localized or generalized osteosclerosis.

  6. Avascular necrosis - Wikipedia

    en.wikipedia.org/wiki/Avascular_necrosis

    Avascular necrosis (AVN), also called osteonecrosis or bone infarction, is death of bone tissue due to interruption of the blood supply. [1] Early on, there may be no symptoms. [1] Gradually joint pain may develop, which may limit the person's ability to move. [1] Complications may include collapse of the bone or nearby joint surface. [1]

  7. Modic changes - Wikipedia

    en.wikipedia.org/wiki/Modic_changes

    Normal bone contains internal scaffolding, called trabeculae. Red bone marrow , which produces blood cells , is located in the hollows between the trabeculae. Modic changes Type 1 reflects oedema adjacent to the disc, fissured endplates, microfractures of the trabeculae, granular tissue, high levels of immunoreactive nerve fibers, and TNF alpha ...

  8. Systemic scleroderma - Wikipedia

    en.wikipedia.org/wiki/Systemic_scleroderma

    Systemic scleroderma, or systemic sclerosis, is an autoimmune rheumatic disease characterised by excessive production and accumulation of collagen, called fibrosis, in the skin and internal organs and by injuries to small arteries. There are two major subgroups of systemic sclerosis based on the extent of skin involvement: limited and diffuse ...

  9. Bone tumor - Wikipedia

    en.wikipedia.org/wiki/Bone_tumor

    A bone tumor is an abnormal growth of tissue in bone, traditionally classified as noncancerous (benign) or cancerous (malignant). [1] [4] Cancerous bone tumors usually originate from a cancer in another part of the body such as from lung, breast, thyroid, kidney and prostate. [1] There may be a lump, pain, or neurological signs from pressure. [1]