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In its simplest form, the oxyhemoglobin dissociation curve describes the relation between the partial pressure of oxygen (x axis) and the oxygen saturation (y axis). Hemoglobin's affinity for oxygen increases as successive molecules of oxygen bind. More molecules bind as the oxygen partial pressure increases until the maximum amount that can be ...
In biochemistry, p50 represents the partial pressure of a gas required to achieve 50% saturation of a particular protein's binding sites. [ 1][ 2] Values of p50 are negatively correlated with substrate affinity; lower values correspond to higher affinity and vice versa. The term is analogous to the Michaelis–Menten constant ( KM ), which ...
The Bohr effect is a phenomenon first described in 1904 by the Danish physiologist Christian Bohr. Hemoglobin 's oxygen binding affinity (see oxygen–haemoglobin dissociation curve) is inversely related both to acidity and to the concentration of carbon dioxide. [1] That is, the Bohr effect refers to the shift in the oxygen dissociation curve ...
Cooperativity. Cooperativity is a phenomenon displayed by systems involving identical or near-identical elements, which act dependently of each other, relative to a hypothetical standard non-interacting system in which the individual elements are acting independently. One manifestation of this is enzymes or receptors that have multiple binding ...
Serious hypoxemia typically occurs when the partial pressure of oxygen in blood is less than 60 mmHg (8.0 kPa), the beginning of the steep portion of the oxygen–hemoglobin dissociation curve, where a small decrease in the partial pressure of oxygen results in a large decrease in the oxygen content of the blood.
Hypoxia is a condition in which the body or a region of the body is deprived of adequate oxygen supply at the tissue level. [1] Hypoxia may be classified as either generalized, affecting the whole body, or local, affecting a region of the body. [2] Although hypoxia is often a pathological condition, variations in arterial oxygen concentrations ...
Oxygen saturation (medicine) Oxygen saturation is the fraction of oxygen -saturated haemoglobin relative to total haemoglobin (unsaturated + saturated) in the blood. The human body requires and regulates a very precise and specific balance of oxygen in the blood. Normal arterial blood oxygen saturation levels in humans are 96–100 percent. [1]
The fetal circulatory system includes three shunts to divert blood from undeveloped and partially functioning organs, as well as blood supply to and from the placenta. In humans, the circulatory system is different before and after birth. The fetal circulation is composed of the placenta, umbilical blood vessels encapsulated by the umbilical ...