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  2. Chronic lymphocytic leukemia - Wikipedia

    en.wikipedia.org/wiki/Chronic_lymphocytic_leukemia

    Chronic lymphocytic leukemia (CLL) is a type of cancer that affects the blood and bone marrow. [8] [9] In CLL, the bone marrow makes too many lymphocytes, which are a type of white blood cell. [8] [9] In patients with CLL, B cell lymphocytes can begin to collect in their blood, spleen, lymph nodes, and bone marrow.

  3. Leukemia - Wikipedia

    en.wikipedia.org/wiki/Leukemia

    Chronic lymphocytic leukemia (CLL) most often affects adults over the age of 55. It sometimes occurs in younger adults, but it almost never affects children. Two-thirds of affected people are men. The five-year survival rate is 85%. [18] It is incurable, but there are many effective treatments.

  4. Treatment can occasionally consist of "watchful waiting" (e.g., in CLL) or symptomatic treatment (e.g., blood transfusions in MDS). The more aggressive forms of disease require treatment with chemotherapy, radiotherapy, immunotherapy and—in some cases—a bone marrow transplant.

  5. Venetoclax - Wikipedia

    en.wikipedia.org/wiki/Venetoclax

    Venetoclax is also indicated as part of a combination therapy for acute myeloid leukemia (AML). [7] For this purpose it is used with azacitidine, decitabine, or low-dose cytarabine for newly diagnosed adults who are age 75 years or older, or those with other health problems where intensive chemotherapy cannot be used.

  6. Chronic leukemia - Wikipedia

    en.wikipedia.org/wiki/Chronic_leukemia

    Chronic leukemia is an increase of abnormal white blood cells. It differs from acute leukemia, and is categorized as myelogenous, lymphocytic or myeloproliferative. Chronic leukemia may refer to: Chronic myelogenous leukemia; Chronic lymphocytic leukemia, including Hairy cell leukemia

  7. Indolent lymphoma - Wikipedia

    en.wikipedia.org/wiki/Indolent_lymphoma

    Chronic lymphocytic leukemia (CLL) and small cell lymphocytic lymphoma (SLL) are different manifestations of the same disease and are managed in the same way. [21] When the abnormal lymphocytes are located mostly in the lymph nodes, it is referred to as SLL; when the abnormal lymphocytes are mostly in the blood and bone marrow, it is called CLL.

  8. Bcl-2 - Wikipedia

    en.wikipedia.org/wiki/Bcl-2

    It was approved by the US FDA in April 2016 as a second-line treatment for CLL associated with 17-p deletion. [36] This was the first FDA approval of a BCL-2 inhibitor. [ 36 ] In June 2018, the FDA broadened the approval for anyone with CLL or small lymphocytic lymphoma, with or without 17p deletion, still as a second-line treatment.

  9. Chlorambucil - Wikipedia

    en.wikipedia.org/wiki/Chlorambucil

    Chlorambucil, sold under the brand name Leukeran among others, is a chemotherapy medication used to treat chronic lymphocytic leukemia (CLL), Hodgkin lymphoma, and non-Hodgkin lymphoma. [2] For CLL it is a preferred treatment. [3] It is given by mouth. [3] Common side effects include bone marrow suppression. [3]