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Mice with severe combined immunodeficiency (SCIDs) are often used in the research of human disease. Human immune cells are used to develop human lymphoid organs within these immunodeficient mice, and many different types of SCID mouse models have been developed.
The Immunologic Constant of Rejection (ICR), is a notion introduced by biologists to group a shared set of genes expressed in tissue destructive-pathogenic conditions like cancer and infection, along a diverse set of physiological circumstances of tissue damage or organ failure, including autoimmune disease or allograft rejection. [1]
A useful model for Alzheimer's disease (AD) in the lab is the Tg2576 strain of mice. The K670M and N671L double mutations seen in the human 695 splice-variant of the amyloid precursor protein (APP) are expressed by this strain.
It is the most widely used "genetic background" for genetically modified mice for use as models of human disease. They are the most widely used and best-selling mouse strain due to the availability of congenic strains, easy breeding, and robustness. [1] The median lifespan of C57BL/6 mice is 27–29 months and the maximum lifespan is about 36 ...
The NOD strain and related strains were developed at Shionogi Research Laboratories in Aburahi, Japan by Makino and colleagues and first reported in 1980. [7] The group developed the NOD strain by an outbreeding of the cataract-prone strain from JcI:ICR mice. [8]
By crossing SCID mice with these other mice, more severely immunocompromised strains can be created to further aid research (e.g. by being less likely to reject transplants). The degree to which the various components of the immune system are compromised varies according to what other mutations the mice carry along with the SCID mutation.
Chile has been hit by its most severe respiratory syncytial virus (RSV) outbreak in years, killing four infants and putting strain on pediatric intensive care unit (ICU) capacity. Yessenia Sanchez ...
Transmitted by the fecal–oral or respiratory route, these viruses infect the livers of mice and have been used as an animal disease model for hepatitis. [10] Transmitted in fecal matter, the strains MHV-D, MHV-DVIM, MHV-Y and MHV-RI mainly infect the digestive tract, sometimes infecting the spleen, liver and lymphatic tissue. [8]