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There is a non-statistically significant increased rate of breast cancer for hormone replacement therapy with synthetic progestogens. [6] The risk may be reduced with bioidentical progesterone, [61] though the only prospective study that suggested this was underpowered due to the rarity of breast cancer in the control population.
The effects of hormonal birth control on breast cancer risk have been studied for decades. Many studies over the years have shown that hormone-containing birth control options, specifically ...
A 2013 meta-analysis concluded that every use of birth control pills is associated with a modest increase in the risk of breast cancer (relative risk 1.08) and a reduced risk of colorectal cancer (relative risk 0.86) and endometrial cancer (relative risk 0.57).
[48] [51] [49] About 5 to 10% of women experience negative mood changes with combined birth control pills, and about 5% of women discontinue birth control pills due to such changes. [ 52 ] [ 48 ] A study of about 4,000 women found that progestogen-only birth control with depot medroxyprogesterone acetate had an incidence of depression of 1.5% ...
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Likewise, other studies found that levels of estradiol and estrone are very similar after oral administration of roughly equimolar doses of estradiol (1.5 mg) and estradiol valerate (2 mg). [110] [111] [112] A study of high-dose oral estradiol valerate found levels of estradiol of about 250 pg/mL after a single 10-mg dose in three women. [107]
Plenty of women don't miss their breasts after surgery — despite the warnings so often coming from breast surgeons society at large: that a life without breasts is one of disfigurement, bereft ...
Staging breast cancer is the initial step to help physicians determine the most appropriate course of treatment. As of 2016, guidelines incorporated biologic factors, such as tumor grade, cellular proliferation rate, estrogen and progesterone receptor expression, human epidermal growth factor 2 (HER2) expression, and gene expression profiling into the staging system.
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