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For example, one study [12] used serial passage in baboons to create a strain of HIV-2 that is particularly virulent to baboons. Typical strains of HIV-2 only infect baboons slowly. [ 12 ] This specificity makes it challenging for scientists to use HIV-2 in animal models of HIV-1, because the animals in the model will only show symptoms slowly.
A chemotherapy regimen is a regimen for chemotherapy, defining the drugs to be used, their dosage, the frequency and duration of treatments, and other considerations.In modern oncology, many regimens combine several chemotherapy drugs in combination chemotherapy.
MRSA can be eradicated with a regimen of linezolid, [87] though treatment protocols vary and serum levels of antibiotics vary widely from person to person and may affect outcomes. [88] The effective treatment of MRSA with linezolid has been successful [87] in 87% of people. Linezolid is more effective in soft tissue infections than vancomycin.
Detailed protocols for proposed clinical studies to assess whether the initial-phase trials will expose the subjects to unnecessary risks. Other commitments are commitments to obtain informed consent from the research subjects, to obtain a review of the study by an institutional review board (IRB), and to adhere to the investigational new drug ...
A 2024 systematic review of the literature found that chemoradiation with 5-FU and mitomycin C, as used in the Nigro Protocol, improves outcomes like colostomy-free survival in anal cancer patients compared to alternatives like cisplatin. However, it can lead to more severe side effects, especially blood-related toxicity. [7]
There is a single type strain for each prokaryotic species, but different culture collections may designate a unique name for the same strain. For example, the type strain of E. coli (originally strain U5/41) is called ATCC 11775 by the American Type Culture Collection, DSM 30083 by the German Collection of Microorganisms and Cell Cultures, JCM ...
Randomized clinical trials analyzed by the intention-to-treat (ITT) approach provide unbiased comparisons among the treatment groups. Intention to treat analyses are done to avoid the effects of crossover and dropout, which may break the random assignment to the treatment groups in a study. ITT analysis provides information about the potential ...
CHOP is the acronym for a chemotherapy regimen used in the treatment of non-Hodgkin lymphoma. CHOP consists of: Cyclophosphamide, an alkylating agent which damages DNA by binding to it and causing the formation of cross-links