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New research finds that millions of people on statins may not need to be taking the drugs. Researchers came to this conclusion after updating the method of assessing an individual’s 10-year risk ...
Overall, our findings suggest that more people over 70 years of age should be considered for statin treatment.” — Borislava Mihaylova, DPhil “Cardiovascular disease remains a leading cause ...
Cholesterol synthesis appears to occur mostly at night, [140] so statins with short half-lives are usually taken at night to maximize their effect. Studies have shown greater LDL and total cholesterol reductions in the short-acting simvastatin taken at night rather than the morning, [141] [142] but have shown no difference in the long-acting ...
A risk exists of muscle damage (myopathy and rhabdomyolysis) with statins. Hypercholesterolemia is not a risk factor for mortality in persons older than 70 years and risks from statin drugs are more increased after age 85. [2] Fibrates are indicated for hypertriglyceridemia. Fibrates typically lower triglycerides by 20% to 50%.
In 1994, the findings of a Merck-funded study were published in The Lancet concluding the efficacy of statins in lowering cholesterol proving for the first time not only that a "statin reduced 'bad' LDL cholesterol but also that it led to a sharp drop in fatal heart attacks among people with heart disease." [112] [116]
Most clinical trials evaluating statins have not included people 75 and older, and it’s been unclear if statins should be used in this age group. The findings suggest the medication can safely ...
[2] [3] They emphasize deprescribing medications that are unnecessary, which helps to reduce the problems of polypharmacy, drug interactions, and adverse drug reactions, thereby improving the risk–benefit ratio of medication regimens in at-risk people. [4] The criteria are used in geriatrics clinical care to monitor and improve the quality of ...
Aluminum and magnesium hydroxide antacids should not be taken within two hours of taking rosuvastatin [4] Coadministration of rosuvastatin with eluxadoline may increase the risk of rhabdomyolysis and myopathy [24] Grapefruit juice negatively interacts with several specific drugs in the statin class, but it has little or no effect on ...
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