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New research finds that millions of people on statins may not need to be taking the drugs. Researchers came to this conclusion after updating the method of assessing an individual’s 10-year risk ...
Cholesterol synthesis appears to occur mostly at night, [140] so statins with short half-lives are usually taken at night to maximize their effect. Studies have shown greater LDL and total cholesterol reductions in the short-acting simvastatin taken at night rather than the morning, [141] [142] but have shown no difference in the long-acting ...
Overall, our findings suggest that more people over 70 years of age should be considered for statin treatment.” — Borislava Mihaylova, DPhil “Cardiovascular disease remains a leading cause ...
Over 45 for men and over 55 for women. Family history. Having a family history of early heart disease. Sex. ... Statins and other cholesterol-lowering drugs. Calcium channel blockers.
Given the potential of statins to exacerbate liver and muscle abnormalities, contraindications of statins include decompensated liver cirrhosis, acute liver failure, unexplained and persistent elevations of serum transaminases, and myopathy. Moreover, statins are not recommended in pregnancy as they may cause foetal harm because of their ...
A risk exists of muscle damage (myopathy and rhabdomyolysis) with statins. Hypercholesterolemia is not a risk factor for mortality in persons older than 70 years and risks from statin drugs are more increased after age 85. [2] Fibrates are indicated for hypertriglyceridemia. Fibrates typically lower triglycerides by 20% to 50%.
Aluminum and magnesium hydroxide antacids should not be taken within two hours of taking rosuvastatin [4] Coadministration of rosuvastatin with eluxadoline may increase the risk of rhabdomyolysis and myopathy [24] Grapefruit juice negatively interacts with several specific drugs in the statin class, but it has little or no effect on ...
Statins appear to be effective at preventing cardiovascular disease and death in older adults, according to new research. Most clinical trials evaluating statins have not included people 75 and ...
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