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Vincamine is a monoterpenoid indole alkaloid found in the leaves of Vinca minor (lesser periwinkle), comprising about 25–65% of its indole alkaloids by weight. It can also be synthesized from related alkaloids.
Vinpocetine is a semi-synthetic derivative of vincamine (sometimes described as "a synthetic ethyl ester of apovincamine"). [14] Minor vinca alkaloids include minovincine, methoxyminovincine, minovincinine, vincadifformine, desoxyvincaminol, and vincamajine. [15] [16] [17]
Vinpocetine (ethyl apovincaminate) is a synthetic derivative of the vinca alkaloid vincamine, differing by the removal of a hydroxyl group and by being the ethyl rather than the methyl ester of the underlying carboxylic acid. Vincamine is extracted from either the seeds of Voacanga africana or the leaves of Vinca minor (lesser periwinkle).
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Psychiatric adverse drug reactions, amnesia. [3] [66] Triparanol: 1962 France, US Cataracts, alopecia, ichthyosis. [3] Troglitazone (Rezulin) 2000 US, Germany Hepatotoxicity [2] Trovafloxacin (Trovan) 1999–2001 European Union, US Withdrawn because of risk of liver failure [2] [3] Valdecoxib (Bextra) 2004 US Risk of heart attack and stroke. [2 ...
Vinca difformis in habitat, Cáceres, Spain. Vinca plants are subshrubs or herbaceous, and have slender trailing stems 1–2 m (3 + 1 ⁄ 2 – 6 + 1 ⁄ 2 ft) long but not growing more than 20–70 cm (8– 27 + 1 ⁄ 2 in) above ground; the stems frequently take root where they touch the ground, enabling the plant to spread widely.
Vinconate is a synthetic vincamine analog used as a nootropic. [1] Vinconate, even when systemically administered, enhances the endogenous release of dopamine in the striatum, probably via the stimulation of presynaptic muscarinic receptors. [2]
Vincaminol (C 20 H 26 N 2 O 2) is a chemical that is a part of the Vinca alkaloid group, which were discovered in the 1950s and are derived from Vinca minor (periwinkle). [1] [2] Vincaminol is not as well known as some of the other Vinca alkaloids such as vinblastine, vinorelbine, vincristine, and vindesine, which are the most medically useful Vinca alkaloids.
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