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[1] [12] The equine estrogens differ from human estrogens in that they have additional double bonds in the B ring of the steroid nucleus. [1] [12] CEEs contain both 17β-estrogens like estradiol and 17β-dihydroequilin and the C17α epimers like 17α-estradiol and 17α-dihydroequilin. [1] [12
Estradiol has been used at high doses to suppress sex drive in men with sexual deviance such as paraphilias and in sex offenders. [84] [85] [86] It has specifically been used for this indication in the forms of intramuscular injections of estradiol valerate and estradiol undecylate and of subcutaneous pellet implants of estradiol. [84] [85] [86]
Tritiated estradiol radioactivity in blood with a single intramuscular injection of 1.5 to 2.8 μg tritiated estradiol in aqueous solution in four women. [1] Peak blood radioactivity occurred within 15 minutes in three of the women and in the remaining woman after 2 hours. [1] Source: Davis et al. (1963). [1]
There is no single definition for the term bioidentical hormone replacement therapy; it is generally used to refer to 17β-estradiol, but other uses include plant-based or compounded estrogen products that blend estradiol with estriol and sometimes with estrone. [9]
This is a list of currently marketed formulations of estradiol benzoate (EB) throughout the world. [1] [2] [3] Both EB alone and combinations of EB with other medications are included.
Estradiol levels with combined injectable contraceptives [16] Preparation Form Dose Estradiol C max Estradiol T max; EV/NETE: Oil solution 5 mg/50 mg 232–428 pg/mL 2 days EC/MPA: Aqueous suspension 5 mg/25 mg 184–736 pg/mL 2–4 days EEn/DHPA: Oil solution 10 mg/150 mg 314–317 pg/mL 4.2–8.1 days 5 mg/75 mg 148 pg/mL 6.5 days
Estrone is an estrogen, specifically an agonist of the estrogen receptors (ERs) ERα and ERβ. [5] [44] It is a far less potent estrogen than is estradiol, and as such is a relatively weak estrogen. [5] [44] Given by subcutaneous injection in mice, estradiol is about 10-fold more potent than estrone and about 100-fold more potent than estriol. [45]
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