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Agouti-signaling protein is a protein that in humans is encoded by the ASIP gene. [5] [6] It is responsible for the distribution of melanin pigment in mammals.[7] [8] Agouti interacts with the melanocortin 1 receptor to determine whether the melanocyte (pigment cell) produces phaeomelanin (a red to yellow pigment), or eumelanin (a brown to black pigment). [9]
An agouti dog, also called wolf sable. In dogs, the agouti gene is associated with various coat colors and patterns. [10]The alleles at the A locus are related to the production of agouti-signaling protein (ASIP) and determine whether an animal expresses an agouti appearance and, by controlling the distribution of pigment in individual hairs, what type of agouti.
AgRP is a paracrine signaling molecule made of 112 amino acids (the gene product of 132 amino acids is processed by removal of the N-terminal 20-residue signal peptide domain). It was independently identified by two teams in 1997 based on its sequence similarity with agouti signalling peptide (ASIP), a protein synthesized in the skin ...
The bay horse, left, has both eumelanin and phaeomelanin in her coat; the agouti signaling peptide suppresses black color to the "points" v the mane, tail, ear tips, and legs. The horse at right lacks the agouti signalling protein, and has a uniformly black or aphaeomelanistic coat.
A cat hair showing agouti coloration A domestic rabbit with agouti coloration. Agouti is a type of fur coloration in which each hair displays two or more bands of pigmentation. [1] [2] The overall appearance of agouti fur is usually gray or dull brown, [3] although dull yellow is also possible.
The Agouti gene, with its dominant A allele and recessive a allele, controls the coding for agouti signaling protein (ASIP; ). The wild-type dominant A causes the banding and thus an overall lightening effect on the hair, while the recessive non-agouti or "hypermelanistic" allele a does not initiate this shift in the pigmentation pathway.
Human chromosome 16 gene stubs (301 P) Pages in category "Genes on human chromosome 16" The following 200 pages are in this category, out of approximately 529 total.
Agouti-signalling protein or ASIP, a circulating hormone encoded by the agouti gene that acts as an antagonist at melanocortin receptors; Agouti-related peptide, a neuropeptide produced in the brain by the AgRP/NPY neuron; Agouti coloration genetics, discussing coat colors created by differences in the agouti gene