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It is thought that it may be caused by the body's inflammatory response to surgery, stress hormone release during surgery, ischemia, or hypoxaemia. [5] [6] Post-operative cognitive dysfunction can complicate a person's recovery from surgery, delay discharge from hospital, delay returning to work following surgery, and reduce a person's quality ...
Postperfusion syndrome, also known as "pumphead", is a constellation of neurocognitive impairments attributed to cardiopulmonary bypass (CPB) during cardiac surgery. Symptoms of postperfusion syndrome are subtle and include defects associated with attention, concentration, short-term memory, fine motor function, and speed of mental and motor ...
Midodrine is a prodrug of its active metabolite desglymidodrine. [3] [1] This metabolite acts as a selective agonist of the α 1-adrenergic receptor. [3] [1] This in turn results in vasoconstriction and increased blood pressure. [3] [1] Midodrine was discovered by 1971 [6] and was introduced for medical use in the United States in 1996 ...
Desglymidodrine (developmental code name ST-1059) is the active metabolite of the prodrug antihypotensive agent midodrine. [1] [2] [3] It acts as a selective α 1-adrenergic receptor agonist. [1] [2] [3] Desglymidodrine is formed from midodrine via deglycination. [1] [2] [3]
The hallmark symptom of LATE is a progressive memory loss that predominantly affects short-term and episodic memory. [1] This impairment is often severe enough to interfere with daily functioning and usually remains the chief neurologic deficit, unlike other types of dementia in which non-memory cognitive domains and behavioral changes might be noted earlier or more prominently. [1]
The term young onset dementia is becoming more widely used to avoid the potential confusion between early onset dementia and early stage dementia This term is now used as presenile dementia which is a historical term of people diagnosed with dementia from a younger age of 51 years old. This is caused by an atypical arterioclerosis of the brain.
A link between these types of drugs and cognitive impairment isn't a totally new discovery, but for the first time, researchers used brain imaging techniques to determine the physical changes ...
Clinically subcortical dementia usually is seen with features like slowness of mental processing, forgetfulness, impaired cognition, lack of initiative-apathy, depressive symptoms (such as anhedonia, negative thoughts, loss of self-esteem and dysphoria), loss of social skills along with extrapyramidal features like tremors and abnormal movements.