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These changes caused drugs made with tetrazole to be contaminated with N-nitrosodimethylamine (NDMA) and N-nitrosodiethylamine (NDEA), which cause genetic damage and cancer. [20] This contamination was not detected until 2018. The incident, according to medicinal chemist and pharmaceutical industry blogger Dr. Derek Lowe, points to a greater ...
A variety of drugs are being developed to introduce small amounts of CO, these drugs are commonly called carbon monoxide-releasing molecules. [ 14 ] [ 22 ] Historically, the therapeutic potential of factitious airs , notably carbon monoxide as hydrocarbonate , was investigated by Thomas Beddoes , James Watt , Tiberius Cavallo , James Lind ...
A total of 8 workers and firefighters were injured. Three workers suffered second and third degree burns. February 23, 1999 - A fire occurred in the crude unit at Tosco Corporation's Avon oil refinery in Martinez. Workers were attempting to replace piping attached to a 150-foot-tall fractionator tower while the process unit was in operation.
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Diesel engine runaway is an occurrence in diesel engines, in which the engine draws extra fuel from an unintended source and overspeeds at higher and higher RPM, producing up to ten times the engine's rated output until destroyed by mechanical failure or bearing seizure due to a lack of lubrication. [1]
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Information on the impacts of these incidents is fragmentary and unsystematic, ranging from thousands of dollars to meet the cost of monitoring analysis, to many millions of dollars due to court prosecutions, bankruptcy, product disposal, compensation for revenue loss, damage to brand or reputation, or loss of life. [1]
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