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[5] Hepatocytes are the main cells of the liver. They are large polyhedral cells, with six surfaces, three of which have a relevant function. The three relevant type of surfaces are sinusoidal, canalicular and intercellular. These surfaces are involved in the exchange of substances between the hepatocyte, the vessels and the biliar canaliculi.
The typical hepatocyte is cubical with sides of 20-30 μm, (in comparison, a human hair has a diameter of 17 to 180 μm). [1] The typical volume of a hepatocyte is 3.4 x 10 −9 cm 3. [2] Smooth endoplasmic reticulum is abundant in hepatocytes, in contrast to most other cell types. [3]
In histology (microscopic anatomy), the lobules of liver, or hepatic lobules, are small divisions of the liver defined at the microscopic scale. The hepatic lobule is a building block of the liver tissue, consisting of portal triads, hepatocytes arranged in linear cords between a capillary network, and a central vein.
General reference for the list of included substances (but not their functions): Table 45–4 in: Walter F., PhD. Boron (2003). Medical Physiology: A Cellular And Molecular Approaoch. Elsevier/Saunders. p. 1300. ISBN 1-4160-2328-3. Other:
The glucokinase regulatory protein (GKRP) also known as glucokinase (hexokinase 4) regulator (GCKR) is a protein produced in hepatocytes (liver cells). GKRP binds and moves glucokinase (GK), thereby controlling both activity and intracellular location [ 1 ] [ 2 ] of this key enzyme of glucose metabolism .
Sometimes, hepatocytes do not have the ability to proliferate and an alternative form of regeneration may take place to rebuild the liver. [5] When hepatocytes or biliary cells are unable or blocked from regeneration, these cell types can function as facultative stem cells for each other. [5] [11] When hepatocytes cannot proliferate, biliary ...
Undifferentiated hepatocyte-like cells appear in small, individualized, colonies The cells are available as undifferentiated growth-stage cells that can be grown in-house with the possibility of cell manipulation and amplification; or as fully differentiated cells that are ready and easy-to-use cells with high inter-assay reproducibility and ...
The LSECs contain 45% and 17% of the liver's total mass of pinocytic vesicles and lysosomes, and contain twice as many clathrin-coated pits per membrane unit, compared with two other major liver cells, Kupffer cells and hepatocytes, [5] reflecting the high capacity clathrin-mediated endocytic activity of LSECs.